ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide

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Chemical Name:ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide
CAS No.:1598420-54-2
Molecular Formula:C₂₈H₃₆N₄O₇
Molecular Weight:540.616
Hs Code.:

Synonyms:ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide

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Chemical Property of ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide

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Technology Process of ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide

There total 4 articles about ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-53-3
Cyclohexyl isocyanide

: 1212264-50-0
(S)-α-(2,4-dimethoxyphenyl)ethylamine

: 99-61-6
3-nitro-benzaldehyde

: 543-24-8
N-acetylglycine

: 1598420-54-2
ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide

: 1598420-59-7
ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide

Guidance literature:: (S)-α-(2,4-dimethoxyphenyl)ethylamine; 3-nitro-benzaldehyde; In ethanol; at 20 ℃; for 0.5h;

Cyclohexyl isocyanide; N-acetylglycine; In ethanol; at 0 - 20 ℃; for 24h; Overall yield = 87 %;
DOI:10.1016/j.tetasy.2014.01.016

Reference yield:

: 829-20-9
2',4'-dimethoxyacetophenone

: 1598420-54-2
ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium carbonate / water / 2 h / 135 °C / Reflux

1.2: Reflux

2.1: sodium hydroxide / water / 4 h / Reflux

3.1: Novozym 435 / toluene / 48 h / 25 °C / Enzymatic reaction

4.1: ethanol / 0.5 h / 20 °C

4.2: 24 h / 0 - 20 °C

With ammonium carbonate; sodium hydroxide; In ethanol; water; toluene; 4.1: |Ugi Condensation / 4.2: |Ugi Condensation;
DOI:10.1016/j.tetasy.2014.01.016

Reference yield:

: C₁₆H₁₇NO₃

: 1598420-54-2
ethyl 2-acetamido-N-[2-(cyclohexylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N-[(S)-1-(2,4-dimethoxyphenyl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 4 h / Reflux

2.1: Novozym 435 / toluene / 48 h / 25 °C / Enzymatic reaction

3.1: ethanol / 0.5 h / 20 °C

3.2: 24 h / 0 - 20 °C

With sodium hydroxide; In ethanol; water; toluene; 3.1: |Ugi Condensation / 3.2: |Ugi Condensation;
DOI:10.1016/j.tetasy.2014.01.016