4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid

Base Information

Chemical Name:4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid
CAS No.:351432-33-2
Molecular Formula:C₁₂H₁₇BO₅
Molecular Weight:252.075
Hs Code.:

Synonyms:4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid

Suppliers and Price of 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid

There total 7 articles about 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 121-43-7,63156-11-6
Trimethyl borate

: 198275-89-7
4-(4-bromophenyloxymethyl)-2,2-dimethyl-1,3-dioxolane

: 351432-33-2
4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid

Guidance literature:: With n-butyllithium; 1. n-C4H9Li, -100°C, 2. B(OCH3)3, 3. phosphate buffer, 0°C;
DOI:10.1021/ja200822z

Reference yield:

: C₁₄H₂₁BO₅

: 351432-33-2
4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid

Guidance literature:: With phosphate buffer; In tetrahydrofuran; hexane; for 1h; pH=4.5 - 5.0;
DOI:10.1021/ja003124k

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 351432-33-2
4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzene boronic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: BBr₃ / CH₂Cl₂ / 20 °C

2.1: K₂CO₃ / acetonitrile / Heating

3.1: OsO₄; NMMNO / acetone / 20 °C

4.1: Py*TsOH / 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -100 °C

5.2: tetrahydrofuran; hexane / -100 - 20 °C

6.1: 10.4 g / aq. phosphate buffer / tetrahydrofuran; hexane / 1 h / pH 4.5 - 5.0

With osmium(VIII) oxide; n-butyllithium; phosphate buffer; pyridinium p-toluenesulfonate; boron tribromide; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; hexane; dichloromethane; acetone; acetonitrile;
DOI:10.1021/ja003124k