Benzenemethanol, 5-amino-2-(4-methyl-1-piperazinyl)- (9CI)

Base Information

• Chemical Name: Benzenemethanol, 5-amino-2-(4-methyl-1-piperazinyl)- (9CI)
• CAS No.: 802541-81-7
• Molecular Formula: C12H19 N3 O
• Molecular Weight: 221.302
• Hs Code.: 2933599090
• Mol file: 802541-81-7.mol

Synonyms:[5-Amino-2-(4-methylpiperazin-1-yl)phenyl]methanol

Chemical Property of Benzenemethanol, 5-amino-2-(4-methyl-1-piperazinyl)- (9CI)

Chemical Property:

• Melting Point: 162～164℃
• PSA: 52.73000
• LogP: 1.09700

Purity/Quality:

99% ^*data from raw suppliers

[5-amino-2-(4-methylpiperazino)phenyl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 5-amino-2-(4-methyl-1-piperazinyl)- (9CI)

There total 8 articles about Benzenemethanol, 5-amino-2-(4-methyl-1-piperazinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methanol (802541-80-6) → (5-amino-2-(4-methylpiperazin-1-yl)phenyl)methanol (802541-81-7)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In ethanol; at 20 ℃;

DOI:10.1515/HC.2010.011

Reference yield:

2-fluoro-5-nitrobenzaldehye (27996-87-8) → (5-amino-2-(4-methylpiperazin-1-yl)phenyl)methanol (802541-81-7)

Guidance literature:

Multi-step reaction with 3 steps

2: 1 h / 130 °C

3: palladium 10% on activated carbon; ammonium formate / ethanol / 20 °C

With palladium 10% on activated carbon; ammonium formate; In ethanol;

DOI:10.1515/HC.2010.011

Reference yield:

1-methyl-piperazine (109-01-3) → (5-amino-2-(4-methylpiperazin-1-yl)phenyl)methanol (802541-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / 130 °C

2: ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

With ammonium formate; palladium 10% on activated carbon; In ethanol;

upstream raw materials:

[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methanol

(2-fluoro-5-nitrophenyl)methanol

2-fluoro-5-nitrobenzaldehye

1-methyl-piperazine

Downstream raw materials:

{5-[(7-chloroquinolin-4-yl)amino]-2-(4-methylpiperazino)phenyl}methanol

7-chloro-N-[4-(4-methylpiperazino)-3-(pyrrolidinomethyl)phenyl]quinolin-4-amine

N-{3-[(tert-butylamino)methyl]-4-(4-methylpiperazino)phenyl}-7-chloroquinolin-4-amine

7-chloro-N-[4-(4-methylpiperazino)-3-(morpholinomethyl)phenyl]quinolin-4-amine