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[2-(4-methylpiperazino)-5-nitrophenyl]methanol, also known as H-151, is a chemical compound with potential therapeutic properties. It is characterized by its ability to inhibit the growth of fungi and has shown promise as a treatment for various fungal infections, particularly those caused by Candida species. [2-(4-methylpiperazino)-5-nitrophenyl]methanol's antifungal activity makes it a valuable drug candidate for the development of new medications in this area. Moreover, it has also demonstrated potential as an antitumor agent in preclinical studies, although further research is necessary to fully comprehend its applications and mechanisms of action.

802541-80-6

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802541-80-6 Usage

Uses

Used in Pharmaceutical Industry:
[2-(4-methylpiperazino)-5-nitrophenyl]methanol is used as an antifungal agent for its inhibitory effects on the growth of fungi, particularly Candida species. This makes it a potentially valuable compound for the development of new antifungal medications to combat fungal infections.
Used in Oncology Research:
In the field of oncology, [2-(4-methylpiperazino)-5-nitrophenyl]methanol is used as a potential antitumor agent. Preclinical studies have shown promising results, indicating that the compound may have applications in the treatment of cancer. However, further research is required to understand its full potential and mechanisms of action in this area.

Check Digit Verification of cas no

The CAS Registry Mumber 802541-80-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,0,2,5,4 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 802541-80:
(8*8)+(7*0)+(6*2)+(5*5)+(4*4)+(3*1)+(2*8)+(1*0)=136
136 % 10 = 6
So 802541-80-6 is a valid CAS Registry Number.

802541-80-6Relevant articles and documents

MACROCYCLIC COMPOUND SERVING AS WEE1 INHIBITOR AND APPLICATIONS THEREOF

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, (2020/11/30)

Disclosed in the present invention are a macrocyclic compound serving as a Weel inhibitor, and applications thereof in the preparation of drugs for treating Weel-related diseases. The present invention specifically relates to a compound represented by for

Pyrrolopyrimidine compound, pharmaceutical composition containing thereof, and preparation method and applications

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, (2019/11/29)

The invention relates to a pyrrolopyrimidine compound represented by formula I, a pharmaceutical composition containing thereof, and a preparation method and applications in preventing or treating Weel protein kinase related diseases.

Macrocyclic derivative of pyrazole[3,4-d]pyrimidin-3-one and pharmaceutical composition and application thereof

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Paragraph 0332; 0408; 0409; 0410, (2018/10/19)

The present invention relates to a macrocyclic derivative of pyrazole[3,4-d]pyrimidin-3-one as shown in the formula (I) and/or a pharmaceutically acceptable salt thereof, and a composition of a compound of the formula (I) and/or a pharmaceutically acceptable salt thereof, a preparation method thereof, application thereof as a Wee1 inhibitor and application thereof as a sensitizer for cancer chemotherapy or radiotherapy. The macrocyclic derivative of pyrazole[3,4-d]pyrimidin-3-one can effectively inhibit Wee1 and related signaling pathways, and has good cancer treatment and/or relieving effect.The formula is shown in the description.

Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7, 26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27) ,16,21,23-decaene (SB1518), a potent Janus Kinase 2/Fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lymphoma

William, Anthony D.,Lee, Angeline C.-H.,Blanchard, Stéphanie,Poulsen, Anders,Teo, Ee Ling,Nagaraj, Harish,Tan, Evelyn,Chen, Dizhong,Williams, Meredith,Sun, Eric T.,Goh, Kee Chuan,Ong, Wai Chung,Goh, Siok Kun,Hart, Stefan,Jayaraman, Ramesh,Pasha, Mohammed Khalid,Ethirajulu, Kantharaj,Wood, Jeanette M.,Dymock, Brian W.

, p. 4638 - 4658 (2011/09/14)

Discovery of the activating mutation V617F in Janus Kinase 2 (JAK2 V617F), a tyrosine kinase critically involved in receptor signaling, recently ignited interest in JAK2 inhibitor therapy as a treatment for myelofibrosis (MF). Herein, we describe the design and synthesis of a series of small molecule 4-aryl-2-aminopyrimidine macrocycles and their biological evaluation against the JAK family of kinase enzymes and FLT3. The most promising leads were assessed for their in vitro ADME properties culminating in the discovery of 21c, a potent JAK2 (IC50 = 23 and 19 nM for JAK2 WT and JAK2V617F, respectively) and FLT3 (IC50 = 22 nM) inhibitor with selectivity against JAK1 and JAK3 (IC50 = 1280 and 520 nM, respectively). Further profiling of 21c in preclinical species and mouse xenograft and allograft models is described. Compound 21c (SB1518) was selected as a development candidate and progressed into clinical trials where it is currently in phase 2 for MF and lymphoma.

7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS

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, (2011/07/07)

The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.

Optimized and convergent synthesis of potent anti-malarial aminoquinoline compounds: Easy access to analogs

Le Fur, Nicolas,Larchanche, Paul-Emmanuel,Melnyk, Patricia

, p. 235 - 239 (2011/06/21)

Amodiaquine is one of the most active antimalarial 4-aminoquinoline. Previously we have described new analogs of amodiaquine and amopyroquine, in which the hydroxyl group was replaced by various amino groups and identified highly potent compounds. Here we

PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES

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, (2009/01/20)

The present invention relates to pyridyl substituted pyrimidine compounds that are useful as agents for the treatment of kinase related disorders such as proliferative disorders. More particularly, the present invention relates to oxygen linked and pyridy

PYRAZOLO-QUINAZOLINE DERIVATIVES,PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

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, (2008/06/13)

Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

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