1-(benzenesulfonyl)-3-bromo-1H-pyrrole

Base Information

• Chemical Name: 1-(benzenesulfonyl)-3-bromo-1H-pyrrole
• CAS No.: 1192217-75-6
• Molecular Formula: C₁₀H₈BrNO₂S
• Molecular Weight: 286.149
• Mol file: 1192217-75-6.mol

Synonyms:1-(benzenesulfonyl)-3-bromo-1H-pyrrole

Chemical Property of 1-(benzenesulfonyl)-3-bromo-1H-pyrrole

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

1-(Benzenesulfonyl)-3-bromo-1H-pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(benzenesulfonyl)-3-bromo-1H-pyrrole

There total 2 articles about 1-(benzenesulfonyl)-3-bromo-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-phenylsulfonylpyrrole (16851-82-4) → 1-(benzenesulfonyl)-3-bromo-1H-pyrrole (1192217-75-6)

Guidance literature:

With bromine; In acetic acid; for 2.5h; Reflux;

DOI:10.1016/j.bmcl.2018.02.013

Reference yield:

benzenesulfonyl chloride (98-09-9) → 1-(benzenesulfonyl)-3-bromo-1H-pyrrole (1192217-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 - 20 °C

1.2: 17 h / 0 - 20 °C

2.1: acetic acid; bromine / 2 h / Reflux

With bromine; sodium hydride; acetic acid; In N,N-dimethyl-formamide; mineral oil;

DOI:10.1002/chem.202003762

Reference yield: 99.0%

1-(benzenesulfonyl)-3-bromo-1H-pyrrole (1192217-75-6) → N-benzenesulfonyl-2,3-dibromopyrrole (1229516-54-4)

Guidance literature:

1-(benzenesulfonyl)-3-bromo-1H-pyrrole; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

With 1,2-dibromo-1,1,2,2-tetrafluoroethane; In tetrahydrofuran; hexane; at -78 ℃; regioselective reaction;

DOI:10.1021/ol100810c

upstream raw materials:

N-phenylsulfonylpyrrole

benzenesulfonyl chloride

Downstream raw materials:

methyl 3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carboxylate

N-benzenesulfonyl-2,3-dibromopyrrole

N-benzenesulfonyl-3-bromo-2-iodopyrrole

C₁₀H₇⁽²⁾HBrNO₂S