(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate
CAS No.:1208330-97-5
Molecular Formula:C₂₄H₂₃ClN₂O₄
Molecular Weight:438.911
Hs Code.:

Synonyms:(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

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Chemical Property of (E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

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Technology Process of (E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

There total 12 articles about (E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1208330-95-3
4-(1-(4-chloro-2-methoxyphenyl)-3-formyl-1H-pyrrol-2-yl)-3-methylbenzamide

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1208330-97-5
(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

: 791-28-6
Triphenylphosphine oxide

Guidance literature:: In toluene; Reflux;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1161274-19-6
4-cyano-2-methylbenzoyl chloride

: 1208330-97-5
(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: ozone / dichloromethane / 1 h / -78 °C

4.1: pyridinium p-toluenesulfonate / ethanol / 6 h / 50 °C

5.1: water; dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

6.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

7.1: manganese(IV) oxide / dichloromethane / 48 h / Reflux

8.1: toluene / Reflux

With manganese(IV) oxide; n-butyllithium; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; ozone; diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide; toluene; mineral oil; 8.1: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1208331-48-9
ethyl 2-(4-cyano-2-methylbenzoyl)pent-4-enoate

: 1208330-97-5
(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

Guidance literature:: Multi-step reaction with 6 steps

1: ozone / dichloromethane / 1 h / -78 °C

2: pyridinium p-toluenesulfonate / ethanol / 6 h / 50 °C

3: water; dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

4: diisobutylaluminium hydride / toluene / 2 h / -78 °C

5: manganese(IV) oxide / dichloromethane / 48 h / Reflux

6: toluene / Reflux

With manganese(IV) oxide; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; ozone; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide; toluene; 6: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086