5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide

Base Information

Chemical Name:5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide
CAS No.:1609428-71-8
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide

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Chemical Property of 5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide

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Technology Process of 5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide

There total 5 articles about 5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.5%

: 1609429-12-0
5-cyano-2-(prop-2-yn-1-yloxy)benzoic acid

: 669067-80-5
4-(6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-yl)-butan-1-amine

: 1609428-71-8
5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1021/jm5001453

Reference yield:

: 84437-12-7
methyl 5-cyanosalicylate

: 1609428-71-8
5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / Reflux; Inert atmosphere

2.1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere

2.2: pH 5 - Ca_. 6 / Inert atmosphere

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil;
DOI:10.1021/jm5001453

Reference yield:

: 1609429-11-9
methyl 5-cyano-2-(prop-2-ynyloxy)benzoate

: 1609428-71-8
5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere

1.2: pH 5 - Ca_. 6 / Inert atmosphere

2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 0 °C / Inert atmosphere

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1021/jm5001453