84437-12-7

Basic information

• Product Name: 5-CYANO-2-HYDROXY-BENZOIC ACID METHYL ESTER
• Synonyms: 5-CYANO-2-HYDROXY-BENZOIC ACID METHYL ESTER;METHYL 5-CYANO-2-HYDROXY-BENZATE;METHYL 2-HYDROXY-5-CYANOBENZOATE;Methyl 5-cyano-2-hydroxybenzenecarboxylate;Methyl 2-hydroxy-5-cyanobenzate;Benzoic acid, 5-cyano-2-hydroxy-, methyl ester
• CAS NO: 84437-12-7
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.16
• Mol File: 84437-12-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 306.735°C at 760 mmHg
• Flash Point: 139.309°C
• Appearance: /
• Density: 1.328g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 2-8°C
• PKA: 7.63±0.18(Predicted)
• CAS DataBase Reference: 5-CYANO-2-HYDROXY-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANO-2-HYDROXY-BENZOIC ACID METHYL ESTER(84437-12-7)
• EPA Substance Registry System: 5-CYANO-2-HYDROXY-BENZOIC ACID METHYL ESTER(84437-12-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 84437-12-7(Hazardous Substances Data)

Usage

General Description

5-Cyano-2-Hydroxy-Benzoic Acid Methyl Ester is an organic compound, falling under the category of aromatic esters. This chemical often comes in the form of a clear, colorless liquid and has an aromatic, slightly pungent odor. It can be synthesized through the esterification of 5-Cyano-2-Hydroxy-Benzoic Acid using methanol as a reactant. It usually exhibits properties of both carboxylic acids and alcohols due to the presence of carbonyl and hydroxyl groups in its structure. Its applications can be found in various industrial uses, specifically in the production of pharmaceutical drugs and other organic synthesis. Methyl esters like this one are typically used as intermediates for the synthesis of other complex compounds.

InChI:InChI=1/C9H7NO3/c1-13-9(12)7-4-6(5-10)2-3-8(7)11/h2-4,11H,1H3

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 
• 557-21-1 zinc(II) cyanide 
• 4068-75-1 methyl 5-iodosalicylate 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 10435-57-1 5-cyano-2-hydroxybenzoic acid 
• 113763-46-5 methyl 5-cyano-2-(4,6-dimethoxypyrimidin-2-yl)oxy benzoate 
• 1609429-11-9 methyl 5-cyano-2-(prop-2-ynyloxy)benzoate 
• 1609428-72-9 5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methoxy)benzamide 
• 1609428-71-8 5-cyano-N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-butyl)-2-(prop-2-ynyloxy)benzamide 
• 1609429-12-0 5-cyano-2-(prop-2-yn-1-yloxy)benzoic acid 
• 1093397-34-2 methyl 3-amino-5-cyano-2-hydroxybenzoate 
• 1093397-35-3 methyl 5-cyano-2-hydroxy-3-nitrobenzoate 
• 1334481-35-4 Methyl 2-(2-(tert-butoxycarbonylamino)ethoxy)-5-cyanobenzoate 
• 518978-03-5 5-cyano-2-[(phenylmethyl)oxy]benzoic acid 
• 1285513-43-0 5-cyano-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide 
• 518978-02-4 methyl 5-cyano-2-[(phenylmethyl)oxy]benzoate 
• 1141474-14-7 methyl 5-[amino(hydroxyimino)methyl]-2-hydroxybenzoate 
• 1065640-40-5 Methyl 5-cyano-2-(2-methoxyethoxy)benzoate 

Relevant articles and documents

NOVEL COMPOUNDS

The present invention discloses novel compounds inhibiting LRRK2 kinase activity, the preparation processes thereof, the compositions containing them, as well as the use in treating diseases characterized by LRRK2 kinase activity, particularly Parkinson's disease and Alzheimer's disease.

ARYL DICARBOXAMIDES

The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycernia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholes-terolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of aryl dicarboxamides of formula (I) to modulate, notably to inhibit the activity of PTPs. A is an airninocarbonyl moiety; Cy is an aryl, heteroaryl, aryl-heteroaryl, heteroaryl-aryl, aryl-aryl, cycloalkyl or heterocycle group; n is either 0 or 1; R1 and R2 are independently from each other is selected from the group consisting of hydrogen or C1-C6-alkyl; R4 and R5 are each independently from each other selected from the group consisting of H, hydroxy, C1-C6 alkyl, carboxy, C1-C6 alkoxy, C1-C3 alkyl carboxy, C2-C3 alkenyl carboxy, C2-C3 alkynyl carboxy, amino or R4 and R5 may form an unsaturated or saturated heterocyclic ring, whereby at least one of R4 or R5 is not a hydrogen or C1-C6 alkyl.

Application of polymer-supported triphenyl phosphine in the palladium-catalyzed cyanation reaction under microwave conditions

A variety of aryl nitriles were prepared in excellent yields from the palladium acetate catalyzed coupling of aryl halides with Zn(CN)2 using polymer-supported triphenyl phosphine as the ligand and dimethylformamide as solvent under microwave irradiation conditions.