N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Base Information

Chemical Name:N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide
CAS No.:106665-46-7
Molecular Formula:C₁₈H₁₉N₅O₄
Molecular Weight:369.38
Hs Code.:

Synonyms:N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Suppliers and Price of N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

There total 6 articles about N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: 19186-33-5
aristeromycin

: 106665-46-7
N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Guidance literature:: aristeromycin; With pyridine; chloro-trimethyl-silane; at 20 ℃; for 2h; Inert atmosphere;

benzoyl chloride; at 0 - 20 ℃; for 19.5h;

Reference yield:

: 143395-28-2
(1R,5R)-5-hydroxymethyl-2-cyclopenten-1-ol

: 106665-46-7
N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP / pyridine

2: 43 percent / Pd(PPh₃)4 / dimethylformamide / 55 °C

3: NaOH / tetrahydrofuran; H₂O

4: OsO₄, trimethylamine N-oxide

With dmap; sodium hydroxide; osmium(VIII) oxide; trimethylamine-N-oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; water; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00619-1

Reference yield:

: 160154-62-1
(S)-2-Acetoxy-propionic acid (3S,3aS,6aR)-2-oxo-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-3-yl ester

: 106665-46-7
N-(9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LiAlH₄, 2.) NaIO₄, 3.) NaBH₄

2: DMAP / pyridine

3: 43 percent / Pd(PPh₃)4 / dimethylformamide / 55 °C

4: NaOH / tetrahydrofuran; H₂O

5: OsO₄, trimethylamine N-oxide

With dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; trimethylamine-N-oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; water; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00619-1