(2S,3R,4S,5S)-N⁽¹⁾-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine

Base Information

• Chemical Name: (2S,3R,4S,5S)-N⁽¹⁾-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine
• CAS No.: 698394-45-5
• Molecular Formula: C₂₁H₃₀INO₄
• Molecular Weight: 487.378

Synonyms:(2S,3R,4S,5S)-N⁽¹⁾-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine

Chemical Property of (2S,3R,4S,5S)-N⁽¹⁾-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R,4S,5S)-N⁽¹⁾-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine

There total 3 articles about (2S,3R,4S,5S)-N⁽¹⁾-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

acetonitrile (75-05-8,26809-02-9) + tert-butyl (3S,4S,5R,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4,5-O-isopropylidene-hepta-6-enoate → N-α-phenylethylacetamide (36065-27-7,6284-14-6) + (2R,3R,4S,5S)-N(1)-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine (698394-46-6) + (2S,3R,4S,5S)-N(1)-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine (698394-45-5)

Guidance literature:

With iodine; sodium hydrogencarbonate; at -20 - 20 ℃; for 22h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.02.014

Reference yield: 51.0%

tert-butyl (3S,4S,5R,αR)-3-[N-benzyl-N-(α-methyl-4'-methoxybenzyl)amino]-4,5-O-isopropylidene-hept-6-enoate (1169755-20-7) + acetonitrile (75-05-8,26809-02-9) → N-[1-(4-methoxy-phenyl)-ethyl]-acetamide (82776-14-5,92520-14-4) + (2R,3R,4S,5S)-N(1)-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine (698394-46-6) + (2S,3R,4S,5S)-N(1)-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine (698394-45-5)

Guidance literature:

With iodine; sodium hydrogencarbonate; at -20 - 20 ℃; for 22h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.02.014

Reference yield: 9.0%

tert-butyl (3S,4S,5R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4,5-O-isopropylidene-hepta-6-enoate (1169755-24-1) + acetonitrile (75-05-8,26809-02-9) → N-α-phenylethylacetamide (36065-27-7,6284-14-6) + (2R,3R,4S,5S)-N(1)-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine (698394-46-6) + (2S,3R,4S,5S)-N(1)-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine (698394-45-5)

Guidance literature:

With iodine; sodium hydrogencarbonate; at -20 - 20 ℃; for 22h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.02.014

upstream raw materials:

acetonitrile

tert-butyl (3S,4S,5R,αR)-3-[N-benzyl-N-(α-methyl-4'-methoxybenzyl)amino]-4,5-O-isopropylidene-hept-6-enoate

tert-butyl (3S,4S,5R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4,5-O-isopropylidene-hepta-6-enoate

Downstream raw materials:

(2R,3R,4S,5S)-N⁽¹⁾-benzyl-2-acetoxymethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 698394-45-5 (2S,3R,4S,5S)-N⁽¹⁾-benzyl-2-iodomethyl-3,4-O-isopropylidene-5-(tert-butoxycarbonylmethyl)pyrrolidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send