1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutanamine

Base Information

Chemical Name:1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutanamine
CAS No.:1439397-18-8
Molecular Formula:C₂₂H₂₀N₄
Molecular Weight:340.428
Hs Code.:

Synonyms:1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutanamine

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Chemical Property of 1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutanamine

Chemical Property:

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Technology Process of 1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutanamine

There total 5 articles about 1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439397-23-5
tert-butyl 1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

: 1439397-18-8
1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutanamine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 13162-26-0
2,4-dichloro-6-methyl-5-nitropyrimidine

: 1439397-18-8
1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium on activated charcoal; potassium acetate; hydrogen / methanol / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere

2.2: 1.5 h / -78 - 20 °C / Inert atmosphere

3.1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 0.25 h / 20 °C / Inert atmosphere

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; acetonitrile / 0.17 h / 80 °C / Inert atmosphere; Microwave irradiation

5.1: hydrogenchloride / ethyl acetate / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; palladium on activated charcoal; hydrogen; potassium acetate; caesium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1439397-21-3
7-iodo-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine

: 1439397-18-8
1-(4-(6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutanamine

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; acetonitrile / 0.17 h / 80 °C / Inert atmosphere; Microwave irradiation

2: hydrogenchloride / ethyl acetate / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; ethyl acetate; acetonitrile;