4-Methylpyrimidin-5-amine

Base Information

• Chemical Name: 4-Methylpyrimidin-5-amine
• CAS No.: 3438-61-7
• Molecular Formula: C5H7N3
• Molecular Weight: 109.131
• Hs Code.: 2933599090
• Mol file: 3438-61-7.mol

Synonyms:Pyrimidine,5-amino-4-methyl- (7CI,8CI);4-Methyl-5-aminopyrimidine;NSC 19151;

Chemical Property of 4-Methylpyrimidin-5-amine

Chemical Property:

• Melting Point: 151-151.5 °C
• Boiling Point: 246.8 °C at 760 mmHg
• PKA: 3.21±0.16(Predicted)
• Flash Point: 126.4 °C
• PSA: 51.80000
• Density: 1.155 g/cm³
• LogP: 0.94840
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-4-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methylpyrimidin-5-amine

There total 4 articles about 4-Methylpyrimidin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-6-methyl-5-nitropyrimidine (13162-26-0) → 5-amino-4-methylpyrimidine (3438-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/charcoal; aq.-ethanolic HCl / Hydrogenation

2: N₂H₄+H₂O; palladium/charcoal; ethanolic KOH

With hydrogenchloride; potassium hydroxide; palladium on activated charcoal; hydrazine hydrate;

Reference yield:

2-chloro-4-methyl-5-aminopyrimidine (20090-69-1) → 5-amino-4-methylpyrimidine (3438-61-7)

Guidance literature:

With phosphonium iodide; hydrogen iodide;

Reference yield:

2-chloro-4-methyl-5-aminopyrimidine (20090-69-1) + hydrogen iodide (10034-85-2) → 5-amino-4-methylpyrimidine (3438-61-7)

Guidance literature:

upstream raw materials:

2-chloro-4-methyl-5-aminopyrimidine

hydrogen iodide

2,4-dichloro-6-methyl-5-nitropyrimidine

Downstream raw materials:

(4-methyl-pyrimidin-5-yl)-(2-nitro-benzyliden)-amine

1H-pyrazolo[4,3-d]pyrimidine

Ro 19194

6-phenyl-5H-pyrrolo[3,2-d]pyrimidine