N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide

Base Information

• Chemical Name: N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide
• CAS No.: 1095004-78-6
• Molecular Formula: C₂₇H₃₀FN₅O₃
• Molecular Weight: 491.565

Synonyms:N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide

Chemical Property of N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide

Chemical Property:

• Density: 1.36±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

AZD-7624 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide

There total 28 articles about N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl[2-[2-[1-[[4-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-3-oxopyrazin-2-yl]amino]cyclopropyl]phenoxy]ethyl]methylamine hemioxalate → N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide (1095004-78-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In water; isopropyl alcohol; at 50 ℃; for 4h; under 3000.3 Torr;

Reference yield: 70.7%

AZD7624*HBr → N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide (1095004-78-6)

Guidance literature:

With sodium hydroxide; In water; ethyl acetate; for 0.5h; Inert atmosphere; Large scale;

DOI:10.1021/acs.oprd.1c00283

Reference yield:

benzyl[2-[2-[1-[[6-bromo-4-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-3-oxo-3,4-dihydro-2-pyrazinyl]amino]cyclopropyl]phenoxy]ethyl]methylcarbamate (1232287-22-7) → N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide (1095004-78-6)

Guidance literature:

With ammonium formate; palladium-carbon; In isopropyl alcohol;

upstream raw materials:

3-[3-[[1-[2-(2-chloroethoxy)phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-5-fluoro-4-methyl-benzamide

methylamine

o-(benzyloxy)benzonitrile

2-chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

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