(3R,4S,5S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone

Base Information

Chemical Name:(3R,4S,5S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone
CAS No.:1577180-38-1
Molecular Formula:C₂₅H₄₃NO₅Si₂
Molecular Weight:493.791
Hs Code.:

Synonyms:(3R,4S,5S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone

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Chemical Property of (3R,4S,5S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone

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Technology Process of (3R,4S,5S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone

There total 3 articles about (3R,4S,5S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₅NO₅

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1577180-38-1
(3R,4S,5S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;
DOI:10.1002/jhet.1634

Reference yield:

: (3R,4R)-3,4-Bis<(tert-butyldimethylsilyl)oxy>-5-acetoxy-1-benzyl-2-pyrrolidinone

: 1577180-38-1
(3R,4S,5S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / toluene / 1 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 5 h / 20 °C / Cooling with ice

3: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Cooling with ice

With 1H-imidazole; hydrogenchloride; boron trifluoride diethyl etherate; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.1634

Reference yield:

: 1577180-36-9
(3R,4S,5R)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-cyano-2-pyrrolidinone

: 1577180-38-1
(3R,4S,5S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 5 h / 20 °C / Cooling with ice

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Cooling with ice

With 1H-imidazole; hydrogenchloride; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.1634