(2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine

Base Information

Chemical Name:(2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine
CAS No.:74974-78-0
Molecular Formula:C₂₁H₂₅N
Molecular Weight:291.436
Hs Code.:

Synonyms:(2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine

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Chemical Property of (2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine

Chemical Property:

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Technology Process of (2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine

There total 9 articles about (2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 74974-80-4
(2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienyl-p-toluenesulfonamide

: 74974-78-0
(2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine

Guidance literature:: With methanol; sodium dihydrogenphosphate; sodium amalgam; at 66 ℃; for 12h;
DOI:10.1021/ja00538a068

Reference yield:

: 13505-32-3
N-tosyl-(S)-phenylalanine

: 74974-78-0
(2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / borane-dimethyl sulfide complex / tetrahydrofuran / 48 h / 25 °C

2: 78 percent / sodium hydride / tetrahydrofuran / 36 h / Heating

3: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 3.5 h / 25 °C

4: 53 percent / sodium hydride / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 25 deg C, 2 h

5: 91 percent / diethyl ether / 0.33 h / -78 °C

6: 95 percent / methanesulfonyl chloride, triethylamine / CH₂Cl₂

7: 95 percent / 6percent sodium amalgam, Na₂HPO₄ / methanol / Heating

With disodium hydrogenphosphate; sodium amalgam; dimethylsulfide borane complex; sodium hydride; methanesulfonyl chloride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja00385a029

Reference yield:

: 82495-70-3
(2S)-2-p-toluenesulfonamido-3-phenylpropanol

: 74974-78-0
(2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / sodium hydride / tetrahydrofuran / 36 h / Heating

2: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 3.5 h / 25 °C

3: 53 percent / sodium hydride / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 25 deg C, 2 h

4: 91 percent / diethyl ether / 0.33 h / -78 °C

5: 95 percent / methanesulfonyl chloride, triethylamine / CH₂Cl₂

6: 95 percent / 6percent sodium amalgam, Na₂HPO₄ / methanol / Heating

With disodium hydrogenphosphate; sodium amalgam; sodium hydride; methanesulfonyl chloride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja00385a029