3,3-Dimethyl-6-oxo-cyclohex-1-enecarboxylic acid benzyl-((E)-(S)-1-benzyl-3,4-dimethyl-penta-2,4-dienyl)-amide

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Chemical Name:3,3-Dimethyl-6-oxo-cyclohex-1-enecarboxylic acid benzyl-((E)-(S)-1-benzyl-3,4-dimethyl-penta-2,4-dienyl)-amide
CAS No.:74974-76-8
Molecular Formula:C₃₀H₃₅NO₂
Molecular Weight:441.613
Hs Code.:

Synonyms:3,3-Dimethyl-6-oxo-cyclohex-1-enecarboxylic acid benzyl-((E)-(S)-1-benzyl-3,4-dimethyl-penta-2,4-dienyl)-amide

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Chemical Property of 3,3-Dimethyl-6-oxo-cyclohex-1-enecarboxylic acid benzyl-((E)-(S)-1-benzyl-3,4-dimethyl-penta-2,4-dienyl)-amide

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Technology Process of 3,3-Dimethyl-6-oxo-cyclohex-1-enecarboxylic acid benzyl-((E)-(S)-1-benzyl-3,4-dimethyl-penta-2,4-dienyl)-amide

There total 8 articles about 3,3-Dimethyl-6-oxo-cyclohex-1-enecarboxylic acid benzyl-((E)-(S)-1-benzyl-3,4-dimethyl-penta-2,4-dienyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 82495-84-9
3,3-dimethyl-6-oxocyclohex-1-ene carboxylic acid

: 74974-78-0
(2S)-(E)-N,N-benzyl-2-(4,5-dimethyl-1-phenyl)hexa-3,5-dienylamine

: 74974-76-8
3,3-Dimethyl-6-oxo-cyclohex-1-enecarboxylic acid benzyl-((E)-(S)-1-benzyl-3,4-dimethyl-penta-2,4-dienyl)-amide

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/ja00538a068

Reference yield:

: 13505-32-3
N-tosyl-(S)-phenylalanine

: 74974-76-8
3,3-Dimethyl-6-oxo-cyclohex-1-enecarboxylic acid benzyl-((E)-(S)-1-benzyl-3,4-dimethyl-penta-2,4-dienyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / BH₃, (CH₃)2S / tetrahydrofuran / 48 h / 25 °C

2: 1.) NaH / 1) THF, 25 deg C, 0.5 h; 2) 65 deg C, 36 h

3: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 3.5 h / 25 °C

4: 53 percent / tetrahydrofuran / 1) 0 deg C, 0.5 h; 2) 25 deg C, 2 h

5: 91 percent / diethyl ether / 0.25 h / -78 °C

6: 85 percent / POCl₃, C₅H₅N / 4 h / 25 °C

7: 95 percent / sodium amalgam, NaH₂PO₄, CH₃OH / 12 h / 66 °C

8: 90 percent / 2-chloro-1-methylpyridinium iodide, (C₂H₅)3N / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; methanol; sodium dihydrogenphosphate; sodium amalgam; dimethylsulfide; borane; 2-chloro-1-methyl-pyridinium iodide; sodium hydride; triethylamine; pyridinium chlorochromate; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00538a068

Reference yield:

: 82495-70-3
(2S)-2-p-toluenesulfonamido-3-phenylpropanol

: 74974-76-8
3,3-Dimethyl-6-oxo-cyclohex-1-enecarboxylic acid benzyl-((E)-(S)-1-benzyl-3,4-dimethyl-penta-2,4-dienyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1) THF, 25 deg C, 0.5 h; 2) 65 deg C, 36 h

2: 75 percent / pyridinium chlorochromate / CH₂Cl₂ / 3.5 h / 25 °C

3: 53 percent / tetrahydrofuran / 1) 0 deg C, 0.5 h; 2) 25 deg C, 2 h

4: 91 percent / diethyl ether / 0.25 h / -78 °C

5: 85 percent / POCl₃, C₅H₅N / 4 h / 25 °C

6: 95 percent / sodium amalgam, NaH₂PO₄, CH₃OH / 12 h / 66 °C

7: 90 percent / 2-chloro-1-methylpyridinium iodide, (C₂H₅)3N / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; methanol; sodium dihydrogenphosphate; sodium amalgam; 2-chloro-1-methyl-pyridinium iodide; sodium hydride; triethylamine; pyridinium chlorochromate; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00538a068