(2R,3R)-4-(2-chlorophenyl)-2-hydroxy-3-[4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoylamino]-butyric acid

Base Information

Chemical Name:(2R,3R)-4-(2-chlorophenyl)-2-hydroxy-3-[4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoylamino]-butyric acid
CAS No.:1415481-83-2
Molecular Formula:C₂₁H₂₀ClN₃O₅
Molecular Weight:429.86
Hs Code.:

Synonyms:(2R,3R)-4-(2-chlorophenyl)-2-hydroxy-3-[4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoylamino]-butyric acid

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Chemical Property of (2R,3R)-4-(2-chlorophenyl)-2-hydroxy-3-[4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoylamino]-butyric acid

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Technology Process of (2R,3R)-4-(2-chlorophenyl)-2-hydroxy-3-[4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoylamino]-butyric acid

There total 6 articles about (2R,3R)-4-(2-chlorophenyl)-2-hydroxy-3-[4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoylamino]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415312-28-5
(2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid Methyl Ester

: 60875-16-3
4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid

: 1415481-83-2
(2R,3R)-4-(2-chlorophenyl)-2-hydroxy-3-[4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoylamino]-butyric acid

Guidance literature:: (2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid Methyl Ester; 4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

With water; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; at 50 ℃;

With acetic acid; In water;

Reference yield:

: 80126-50-7
(R)-2'-chlorophenylalanine

: 1415481-83-2
(2R,3R)-4-(2-chlorophenyl)-2-hydroxy-3-[4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoylamino]-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / 0 °C

1.2: 4 h / pH 8 - 9

1.3: pH 1

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 °C

4.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C

5.1: hydrogenchloride / 1,4-dioxane / Reflux

5.2: 4 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

6.2: 50 °C

With hydrogenchloride; lithium aluminium tetrahydride; water; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1415312-26-3
[(R)-1-(2-chloro-benzyl)-2-cyano-2-hydroxy-ethyl]-carbamic acid benzyl ester

: 1415481-83-2
(2R,3R)-4-(2-chlorophenyl)-2-hydroxy-3-[4-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-benzoylamino]-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / Reflux

1.2: 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

2.2: 50 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide;