(3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-bromomethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Base Information

• Chemical Name: (3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-bromomethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one
• CAS No.: 209804-28-4
• Molecular Formula: C₄₄H₅₃BrN₄O₄Si
• Molecular Weight: 809.919

Synonyms:(3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-bromomethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Chemical Property of (3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-bromomethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Chemical Property:

Purity/Quality:

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Technology Process of (3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-bromomethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

There total 5 articles about (3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-bromomethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-hydroxymethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one (209804-27-3) → (3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-bromomethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one (209804-28-4)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1021/jm980103g

Reference yield:

3-methoxycarbonylbenzyl bromide (1129-28-8) → (3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-bromomethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one (209804-28-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide

2: 1.1 g / LiAlH₄ / 2 h / Ambient temperature

3: 0.6 g / CBr₄, Ph₃P / CH₂Cl₂ / 4 h / 0 - 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980103g

Reference yield:

(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-5-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one → (3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-bromomethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one (209804-28-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide

2: 1.1 g / LiAlH₄ / 2 h / Ambient temperature

3: 0.6 g / CBr₄, Ph₃P / CH₂Cl₂ / 4 h / 0 - 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980103g

upstream raw materials:

(3aS,4R,8R,8aS)-4,8-Dibenzyl-5-(3-hydroxymethyl-benzyl)-2,2-dimethyl-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

3-methoxycarbonylbenzyl bromide

3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-benzoic acid methyl ester

Downstream raw materials:

{3-[(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-dihydroxy-3-(1H-indazol-5-ylmethyl)-2-oxo-[1,3]diazepan-1-ylmethyl]-phenyl}-acetic acid methyl ester

2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide

(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetonitrile

(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-5-(3-pyrazol-1-ylmethyl-benzyl)-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

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