2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide

Base Information

Chemical Name:2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide
CAS No.:209804-31-9
Molecular Formula:C₄₅H₅₅N₅O₅Si
Molecular Weight:774.048
Hs Code.:

2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide

Synonyms:2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide

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Chemical Property of 2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide

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Technology Process of 2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide

There total 7 articles about 2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209804-29-5
(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetonitrile

: 209804-31-9
2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide

Guidance literature:: With dihydrogen peroxide; potassium carbonate; In dimethyl sulfoxide; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm980103g

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 209804-31-9
2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / dimethylformamide

2: 1.1 g / LiAlH₄ / 2 h / Ambient temperature

3: 0.6 g / CBr₄, Ph₃P / CH₂Cl₂ / 4 h / 0 - 20 °C

4: 0.55 g / H₂O; dioxane / 60 °C

5: 0.55 g / aq. 30percent H₂O₂, K₂CO₃ / dimethylsulfoxide / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; dihydrogen peroxide; sodium hydride; potassium carbonate; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm980103g

Reference yield:

: (3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-5-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

: 209804-31-9
2-(3-{(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-6-oxo-7-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-ylmethyl]-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl}-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / dimethylformamide

2: 1.1 g / LiAlH₄ / 2 h / Ambient temperature

3: 0.6 g / CBr₄, Ph₃P / CH₂Cl₂ / 4 h / 0 - 20 °C

4: 0.55 g / H₂O; dioxane / 60 °C

5: 0.55 g / aq. 30percent H₂O₂, K₂CO₃ / dimethylsulfoxide / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; dihydrogen peroxide; sodium hydride; potassium carbonate; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm980103g