phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

Base Information

• Chemical Name: phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester
• CAS No.: 233281-37-3
• Molecular Formula: C₇₃H₁₃₀N₂O₆
• Molecular Weight: 1131.85
• Mol file: 233281-37-3.mol

Synonyms:phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

Chemical Property of phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

There total 7 articles about phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester (233281-34-0) → phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester (233281-37-3)

Guidance literature:

With piperidine; In dichloromethane;

DOI:10.1246/bcsj.74.733

Reference yield:

methyl galloate (99-24-1) → phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester (233281-37-3)

Guidance literature:

Multi-step reaction with 6 steps

1: K₂CO₃ / dimethylformamide / 5 h / 70 °C

2: LiAlH₄ / diethyl ether / 2 h / Heating

3: 63 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / CH₂Cl₂

4: 92 percent / piperidine / CH₂Cl₂

5: 67 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / CH₂Cl₂

6: 92 percent / piperidine / CH₂Cl₂

With piperidine; lithium aluminium tetrahydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.74.733

Reference yield:

3,4,5-trihydroxybenzoic acid (149-91-7) → phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester (233281-37-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 81 percent / H₂SO₄

2: K₂CO₃ / dimethylformamide / 5 h / 70 °C

3: LiAlH₄ / diethyl ether / 2 h / Heating

4: 63 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / CH₂Cl₂

5: 92 percent / piperidine / CH₂Cl₂

6: 67 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / CH₂Cl₂

7: 92 percent / piperidine / CH₂Cl₂

With piperidine; lithium aluminium tetrahydride; sulfuric acid; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.74.733

upstream raw materials:

N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

3,4,5-trihydroxybenzoic acid

methyl galloate

methyl [3,4,5-tris(n-octadecan-1-yloxy)]benzoate