N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

Base Information

Chemical Name:N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester
CAS No.:233281-34-0
Molecular Formula:C₈₈H₁₄₀N₂O₈
Molecular Weight:1354.09
Hs Code.:

Synonyms:N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

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Chemical Property of N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

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Technology Process of N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

There total 6 articles about N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 35661-40-6
N-Fmoc L-Phe

: 233281-33-9
alanine 3,4,5-tris(octadecyloxy)benzyl ester

: 233281-34-0
N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 10h;
DOI:10.1081/SCC-100105332

Reference yield:

: 149-91-7
3,4,5-trihydroxybenzoic acid

: 233281-34-0
N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / H₂SO₄

2: K₂CO₃ / dimethylformamide / 5 h / 70 °C

3: LiAlH₄ / diethyl ether / 2 h / Heating

4: 63 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / CH₂Cl₂

5: 92 percent / piperidine / CH₂Cl₂

6: 67 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / CH₂Cl₂

With piperidine; lithium aluminium tetrahydride; sulfuric acid; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.74.733

Reference yield:

: 99-24-1
methyl galloate

: 233281-34-0
N-(9-fluorenylmethyloxycarbonyl)phenylalanylalanine 3,4,5-tris(octadecyloxy)benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 5 h / 70 °C

2: LiAlH₄ / diethyl ether / 2 h / Heating

3: 63 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / CH₂Cl₂

4: 92 percent / piperidine / CH₂Cl₂

5: 67 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole; Et₃N / CH₂Cl₂

With piperidine; lithium aluminium tetrahydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.74.733