tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate

Base Information

Chemical Name:tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate
CAS No.:1388892-62-3
Molecular Formula:C₂₀H₂₉N₃O₃S
Molecular Weight:391.535
Hs Code.:

Synonyms:tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate

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Chemical Property of tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate

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Technology Process of tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate

There total 2 articles about tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1388892-54-3
C₁₉H₂₇N₃O₃S

: 74-88-4
methyl iodide

: 1388892-62-3
tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate

Guidance literature:: C₁₉H₂₇N₃O₃S; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

methyl iodide; In N,N-dimethyl-formamide; at 20 - 30 ℃;

Reference yield:

: 108831-68-1
4-chloro-5,6-dimethyl-thieno[2,3-d]pyrimidine

: 1388892-62-3
tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

1.2: 20 - 30 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

2.2: 20 - 30 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 64.0%

: 1388892-62-3
tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate

: 74-88-4
methyl iodide

: 1388892-60-1
4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]-N-methylcyclohexan-1-amine

Guidance literature:: tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate; With hydrogenchloride; In dichloromethane; at 0 ℃; for 2h;

methyl iodide; In N,N-dimethyl-formamide; at 20 - 30 ℃;