2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

Base Information

Chemical Name:2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester
CAS No.:210988-88-8
Molecular Formula:C₅₅H₄₉N₇O₅
Molecular Weight:888.038
Hs Code.:

2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

Synonyms:2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

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Chemical Property of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

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Technology Process of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

There total 10 articles about 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 210988-88-8
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / pyridine / 1.5 h

2: 71 percent / NaH / dimethylformamide / Ambient temperature

3: 91 percent / AcOH / ethanol / 3 h / Heating

4: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

5: 86 percent / Et₃N / dimethylformamide

6: 1.) 0.1N ethanolic KOH, 2.) NaI / 2.) DMF, 3 h

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973

Reference yield:

: ethyl N-cyanovalerimidate

: 210988-88-8
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N / ethanol / Ambient temperature

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

3: NaH / dimethylformamide / 3 h / Ambient temperature

4: 72 percent / pyridine / 1.5 h

5: 71 percent / NaH / dimethylformamide / Ambient temperature

6: 91 percent / AcOH / ethanol / 3 h / Heating

7: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

8: 86 percent / Et₃N / dimethylformamide

9: 1.) 0.1N ethanolic KOH, 2.) NaI / 2.) DMF, 3 h

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973

Reference yield:

: 133614-30-9
N-(N'-cyanovalerimidolyl)glycine ethyl ester

: 210988-88-8
2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-oxo-1,3-dihydro-isobenzofuran-1-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

2: NaH / dimethylformamide / 3 h / Ambient temperature

3: 72 percent / pyridine / 1.5 h

4: 71 percent / NaH / dimethylformamide / Ambient temperature

5: 91 percent / AcOH / ethanol / 3 h / Heating

6: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

7: 86 percent / Et₃N / dimethylformamide

8: 1.) 0.1N ethanolic KOH, 2.) NaI / 2.) DMF, 3 h

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.973