6-acetyl-2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Base Information

Chemical Name:6-acetyl-2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS No.:864927-71-9
Molecular Formula:C₁₇H₂₃N₃O₃S
Molecular Weight:349.454
Hs Code.:

Synonyms:6-acetyl-2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

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Chemical Property of 6-acetyl-2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

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Technology Process of 6-acetyl-2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

There total 4 articles about 6-acetyl-2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1585245-08-4
C₁₅H₂₁N₃O₂S*C₂HF₃O₂

: 75-36-5
acetyl chloride

: 864927-71-9
6-acetyl-2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.02.028

Reference yield:

: 1001020-08-1
tert-butyl 2-amino-3-carbamoyl-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate

: 864927-71-9
6-acetyl-2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

2: dichloromethane / 2 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2014.02.028

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 864927-71-9
6-acetyl-2-(cyclohexanecarboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfur; morpholine / ethanol / 12 h / 20 °C

2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

3: dichloromethane / 2 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

With morpholine; benzotriazol-1-ol; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane; 1: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.ejmech.2014.02.028