2,2'-(3,3'-(1,4-phenylene)bis(propane-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid

Base Information

Chemical Name:2,2'-(3,3'-(1,4-phenylene)bis(propane-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid
CAS No.:946055-39-6
Molecular Formula:C₂₆H₄₀N₂O₈
Molecular Weight:508.612
Hs Code.:

Synonyms:2,2'-(3,3'-(1,4-phenylene)bis(propane-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid

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Chemical Property of 2,2'-(3,3'-(1,4-phenylene)bis(propane-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid

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Technology Process of 2,2'-(3,3'-(1,4-phenylene)bis(propane-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid

There total 3 articles about 2,2'-(3,3'-(1,4-phenylene)bis(propane-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 946055-37-4
2,2'-(3,3'-(1,4-phenylene)bis(prop-2-yne-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid

: 946055-39-6
2,2'-(3,3'-(1,4-phenylene)bis(propane-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; under 750.075 Torr;
DOI:10.1021/jm070552t

Reference yield:

: 4530-20-5
BOC-glycine

: 946055-39-6
2,2'-(3,3'-(1,4-phenylene)bis(propane-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / NaH / dimethylformamide; toluene / 0 - 20 °C

2: 58 percent / Et₃N; CuI / PdCl₂(PPh₃)2 / dimethylformamide / 80 °C

3: 91 percent / H₂ / Pd/C / methanol / 20 °C / 750.08 Torr

With copper(l) iodide; hydrogen; sodium hydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; toluene; 2: Sonogashira-Linstrumelle coupling;
DOI:10.1021/jm070552t

Reference yield:

: 158979-29-4
2-((tert-butoxycarbonyl)(prop-2-yn-1-yl)-amino)acetic acid

: 946055-39-6
2,2'-(3,3'-(1,4-phenylene)bis(propane-3,1-diyl))bis(tert-butoxycarbonylazanediyl)diacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / Et₃N; CuI / PdCl₂(PPh₃)2 / dimethylformamide / 80 °C

2: 91 percent / H₂ / Pd/C / methanol / 20 °C / 750.08 Torr

With copper(l) iodide; hydrogen; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1: Sonogashira-Linstrumelle coupling;
DOI:10.1021/jm070552t