2-methyl-2-(3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)butan-1-amine

Base Information

Chemical Name:2-methyl-2-(3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)butan-1-amine
CAS No.:1160500-07-1
Molecular Formula:C₁₈H₂₂N₄
Molecular Weight:294.399
Hs Code.:

Synonyms:2-methyl-2-(3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)butan-1-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-2-(3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)butan-1-amine

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Technology Process of 2-methyl-2-(3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)butan-1-amine

There total 10 articles about 2-methyl-2-(3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)butan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1160499-23-9
C₁₈H₁₈N₄

: 1160500-07-1
2-methyl-2-(3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)butan-1-amine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/acsmedchemlett.9b00134

Reference yield:

: 861881-02-9
4-iodo-1H-pyrazolo[3,4-b]pyridine

: 1160500-07-1
2-methyl-2-(3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)butan-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h

1.2: 2.5 h / 0 - 20 °C

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 110 °C / Inert atmosphere; Sealed tube

3.1: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 60 °C / Inert atmosphere

4.1: trifluoroacetic acid; triethylsilane / dichloromethane / 0 - 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

With triethylsilane; lithium aluminium tetrahydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium acetate; sodium hydride; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acsmedchemlett.9b00134

Reference yield:

: C₂₅H₁₈IN₃

: 1160500-07-1
2-methyl-2-(3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)butan-1-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 110 °C / Inert atmosphere; Sealed tube

2: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 60 °C / Inert atmosphere

3: trifluoroacetic acid; triethylsilane / dichloromethane / 0 - 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

With triethylsilane; lithium aluminium tetrahydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium acetate; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/acsmedchemlett.9b00134