861881-02-9

Basic information

• Product Name: 4-IODO-7-AZA-1H-INDAZOLE
• Synonyms: 4-IODO-7-AZA-1H-INDAZOLE;1H-Pyrazolo[3,4-b]pyridine, 4-iodo-;4-IODO-1H-PYRAZOLO[3,4-B]PYRIDINE
• CAS NO: 861881-02-9
• Molecular Formula: C₆H₄IN₃
• Molecular Weight: 245.019
• EINECS: 200-589-5
• Mol File: 861881-02-9.mol

Chemical Properties

• Boiling Point: 379.8±22.0 °C at 760 mmHg
• Flash Point: 183.5±22.3 °C
• Appearance: /
• Density: 2.2±0.1 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.88±0.40(Predicted)
• CAS DataBase Reference: 4-IODO-7-AZA-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-7-AZA-1H-INDAZOLE(861881-02-9)
• EPA Substance Registry System: 4-IODO-7-AZA-1H-INDAZOLE(861881-02-9)

Safety Data

• Hazardous Substances Data: 861881-02-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-IODO-7-AZA-1H-INDAZOLE is used as a key intermediate in the synthesis of pharmaceutical compounds for the development of new drugs. Its unique structural features contribute to the creation of novel therapeutic agents with potential applications in various medical fields.
Used in Chemical Research:
In the realm of chemical research, 4-IODO-7-AZA-1H-INDAZOLE serves as a valuable building block for the synthesis of complex organic molecules. Its reactivity and structural attributes make it instrumental in the exploration of new chemical reactions and the discovery of innovative synthetic pathways.
Used in Drug Development:
4-IODO-7-AZA-1H-INDAZOLE is employed as a precursor in the development of new drug candidates, leveraging its chemical properties to enhance the pharmacological profiles of potential therapeutic agents. Its incorporation into drug molecules can lead to improved efficacy, selectivity, and safety profiles.
Used in Scientific Studies:
4-IODO-7-AZA-1H-INDAZOLE is utilized as a research tool in scientific studies aimed at understanding the properties and reactivity of indazole derivatives. It aids researchers in probing the structure-activity relationships and the underlying mechanisms of action for this class of compounds, thereby advancing the knowledge base in medicinal chemistry and related fields.
Used in Industrial Applications:
4-IODO-7-AZA-1H-INDAZOLE finds applications in various industrial processes, particularly in the synthesis of specialty chemicals and materials that require the unique structural and functional attributes provided by this compound. Its versatility and reactivity make it a valuable component in the development of new industrial products and technologies.

Upstream product

• 153034-82-3 [(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde 

Downstream Products

• 1378652-03-9 1H-pyrazolo[3,4-b]pyridine-4-carbonitrile 
• 1160502-12-4 4-iodo-1-trityl-1H-pyrazolo[3,4-b]pyridine 
• 1160502-23-7 3-chloro-4-iodo-1H-pyrazolo[3,4-b]pyridine 
• 1160498-53-2 C₁₅H₁₁N₃O 
• 1160498-32-7 2-(3-bromo-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-2-methylpropanenitrile 
• 1160498-05-4 2-(3-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-2-methylpropanenitrile 
• 1196875-94-1 4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-b]pyridine 
• 1198437-88-5 4-iodo-1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyridine 
• 1192004-70-8 ethyl 2-(4-iodo-1H-pyrazolo[3,4-b]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate 
• 1160502-13-5 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine 
• 1160498-70-3 2-(3-(1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl)-2-methylbutan-1-amine 

Relevant articles and documents

SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF

Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.

BIARYL KINASE INHIBITORS

The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.

EP1 RECEPTOR LIGANDS

The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.

1,2,4-TRIAZINE-6-CARBOXAMIDE KINASE INHIBITORS

Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

[1H- PYRAZOLO [3, 4-B] PYRIDINE-4-YL] -PHENYLE OR -PYRIDIN-2-YLE DERIVATIVES AS PROTEIN KINASE C-THETA

The present invention relates to compounds of formula (I) and (IA) useful as inhibitors of protein kinase (1a). The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. (a) : in particular protein kinase C theta, wherein A and A' are independently -N- or -C(R+) -. Ring B is five- or six-membered saturated carbocyclic or heterocyclic R1, R2, R3, R4, R5, R6, R7, x and y are as described herein.

Glucokinase Activators

Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

COMPOUNDS AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.