N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide

Base Information

Chemical Name:N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide
CAS No.:1365879-47-5
Molecular Formula:C₁₄H₁₇BrN₄O
Molecular Weight:337.219
Hs Code.:

Synonyms:N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide

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Technology Process of N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide

There total 1 articles about N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1289386-60-2
N-[(2-bromopyridin-4-yl)methyl]propan-2-amine

: 41716-18-1
1-methylimidazole-4-carboxylic acid

: 1365879-47-5
N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide

Guidance literature:: With 1-hydroxy-1H-benzotriazol hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃;
DOI:10.1248/cpb.c16-00610

Reference yield: 98.0%

: 1365879-47-5
N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1-methyl-N-(propan-2-yl)-N-({2-[4-(trifluoromethyl)-phenyl]pyridin-4-yl}methyl)-1H-imidazole-4-carboxamide bishydrochloride

Guidance literature:: N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide; 4-trifluoromethylphenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Alkaline conditions; Microwave irradiation;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4.5h;
DOI:10.1248/cpb.c16-00610

Reference yield: 95.0%

: 1365879-47-5
N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1-methyl-N-(propan-2-yl)-N-({2-[4-(trifluoromethoxy)-phenyl]pyridin-4-yl}methyl)-1H-imidazole-4-carboxamide bishydrochloride

Guidance literature:: N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide; 4-trifluoromethoxyphenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Alkaline conditions; Microwave irradiation;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4.5h;
DOI:10.1248/cpb.c16-00610