1289386-60-2

Basic information

• Product Name: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine
• Synonyms: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine;2-Bromo-N-(1-methylethyl)-4-pyridinemethanamine;N-[(2-Bromopyridin-4-yl)methyl]propan-2-amine
• CAS NO: 1289386-60-2
• Molecular Formula: C9H13BrN2
• Molecular Weight: 229
• Mol File: 1289386-60-2.mol

Chemical Properties

• Appearance: /
• Density: 1.317
• CAS DataBase Reference: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine(1289386-60-2)
• EPA Substance Registry System: (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine(1289386-60-2)

Safety Data

• Hazardous Substances Data: 1289386-60-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine serves as a valuable building block in the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure, which includes an isopropyl group and amine functionality, contributes to its versatility as an intermediate in the synthesis of complex organic molecules.
Used in Chemical Research:
(2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine also finds application as a reagent in chemical research, where it aids in the investigation of various chemical reactions and processes. Its presence can provide insights into reaction mechanisms and help in the development of new synthetic methodologies.
Used in Specialty Chemicals Production:
Furthermore, (2-Bromo-pyridin-4-ylmethyl)-isopropyl-amine is utilized in the production of specialty chemicals for diverse industrial applications. Its unique properties make it suitable for creating compounds with specific characteristics required in various industries, such as the manufacturing of high-performance materials or the development of novel chemical processes.

Upstream product

• 118289-17-1 2-bromopyridine-4-carboxaldehyde 
• 75-31-0 isopropylamine 

Downstream Products

• 1366407-06-8 N-{[2-(4-Fluorophenyl)pyridin-4-yl]methyl}propan-2-amine 
• 1365879-47-5 N-[(2-bromopyridin-4-yl)methyl]-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide 
• 1366404-54-7 1-methyl-N-[(2-phenylpyridin-4-yl)methyl]-N-(propan-2-yl)-1H-imidazole-4-carboxamide 
• 1366404-68-3 N-{[2-(3-fluorophenyl)pyridin-4-yl]methyl}-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide 

Relevant articles and documents

Identification of 1-methyl-N-(propan-2-yl)-N-({2-[4-(trifluoromethoxy)-phenyl]pyridin-4-yl}methyl)-1H-imidazole-4-carboxamide as a potent and orally available glycine transporter 1 inhibitor

We previously identified 3-chloro-N-{(S)-[3-(1-ethyl-1H-pyrazol-4-yl)phenyl][(2S)-piperidine-2-yl]methyl}-4-(trifluoromethyl)pyridine-2-carboxamide (5, TP0439150) as a potent and orally available glycine transporter 1 (GlyT1) inhibitor. In this article, we describe our identification of 1-methyl-N-(propan-2-yl)-N-({2-[4-(trifluoromethoxy)phenyl]pyridin-4-yl}methyl)-1H-imidazole-4-carboxamide (7n) as a structurally diverse back-up compound of 5, using central nervous system multiparameter optimization (CNS MPO) as a druglikeness guideline. Compound 7n showed a higher CNS MPO score and different physicochemical properties as compared to 5. Compound 7n exhibited potent GlyT1 inhibitory activity, a favorable pharmacokinetics profile, and elicited an increase in the cerebrospinal fluid (CSF) concentration of glycine in rats.

GLYCINE TRANSPORTER INHIBITING SUBSTANCES

The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder: