N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide

Base Information

Chemical Name:N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide
CAS No.:188058-88-0
Molecular Formula:C₄₃H₅₂N₈O₄S₂
Molecular Weight:809.069
Hs Code.:

Synonyms:N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide

Suppliers and Price of N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide

Chemical Property:

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Technology Process of N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide

There total 6 articles about N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22948-02-3
3-aminothiophenol

: 188058-88-0
N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / sodium acetate / ethanol / 36 h / Heating

2: 73 percent / pyridine / diethyl ether / 1) 0 deg C, 1 h; 2) rt, 7 h

3: 80 percent / H₂ / act. Ni / ethanol / 5 h / 80 °C / 75006 Torr

4: 1-ethylpiperidine / tetrahydrofuran / 1) 0 deg C, 1 h; 2) rt, 30 min

5: tetrahydrofuran / 4 h / Heating

With 1-ethyl-piperidine; pyridine; hydrogen; sodium acetate; nickel; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/S0223-5234(97)84360-7

Reference yield:

: 93352-49-9
4-amino-2'-nitrodiphenyl sulfide

: 188058-88-0
N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / pyridine / diethyl ether / 1) 0 deg C, 1 h; 2) rt, 7 h

2: 80 percent / H₂ / act. Ni / ethanol / 5 h / 80 °C / 75006 Torr

3: 1-ethylpiperidine / tetrahydrofuran / 1) 0 deg C, 1 h; 2) rt, 30 min

4: tetrahydrofuran / 4 h / Heating

With 1-ethyl-piperidine; pyridine; hydrogen; nickel; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/S0223-5234(97)84360-7

Reference yield:

: 88-73-3
2-Chloronitrobenzene

: 188058-88-0
N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / sodium acetate / ethanol / 36 h / Heating

2: 73 percent / pyridine / diethyl ether / 1) 0 deg C, 1 h; 2) rt, 7 h

3: 80 percent / H₂ / act. Ni / ethanol / 5 h / 80 °C / 75006 Torr

4: 1-ethylpiperidine / tetrahydrofuran / 1) 0 deg C, 1 h; 2) rt, 30 min

5: tetrahydrofuran / 4 h / Heating

With 1-ethyl-piperidine; pyridine; hydrogen; sodium acetate; nickel; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/S0223-5234(97)84360-7