93352-49-9

Upstream product

• 22948-02-3 3-aminothiophenol 
• 88-73-3 2-Chloronitrobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 6976-04-1 sodium 4-aminothiophenolate 

Downstream Products

• 188058-55-1 Pentanedioic acid bis-{[3-(2-nitro-phenylsulfanyl)-phenyl]-amide} 
• 188058-80-2 Heptanedioic acid bis-{[3-(2-nitro-phenylsulfanyl)-phenyl]-amide} 
• 27332-24-7 3-(2-amino)phenylthiophenylamine 
• 188058-86-8 N,N'-Bis-[3-(2-nitro-phenylsulfanyl)-phenyl]-malonamide 
• 188058-83-5 Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide] 
• 188058-61-9 Pentanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide] 
• 188058-88-0 N,N'-Bis-(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-malonamide 
• 188058-64-2 Pentanedioic acid bis-({3-[2-(3-dimethylamino-propionylamino)-phenylsulfanyl]-phenyl}-amide) 
• 188058-82-4 Heptanedioic acid bis-{[3-(2-amino-phenylsulfanyl)-phenyl]-amide} 
• 188058-58-4 Pentanedioic acid bis-{[3-(2-amino-phenylsulfanyl)-phenyl]-amide} 
• 188058-73-3 3-(4-Methyl-piperazin-1-yl)-N-(2-{3-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-propionamide 
• 188058-87-9 N,N'-Bis-[3-(2-amino-phenylsulfanyl)-phenyl]-malonamide 

Relevant academic research and scientific papers

Synthesis of 4-amino-2′-nitrodiphenyl sulfide

A method of synthesis of 4-amino-2′-nitrodiphenyl sulfide in an yield of up to 85% and a purity of no less that 93% is proposed. The method involves reaction of 4-chloronitrobenzene with sodium sulfide in water and subsequent reaction of the resulting int

New potent inhibitors of trypanothione reductase from Trypanosoma cruzi in the 2-aminodiphenylsulfide series

From a screening assay, 2-aminodiphenylsulfides were selected as leads for trypanothione reductase (TR) inhibition and studied by molecular modelling in the catalytic site of the enzyme. A series of analogues, monomers or bis-derivatives, were synthesized to improve binding energy and therefore inhibiting potency. These compounds appeared to be mixed competitive TR inhibitors and their inhibition profile could be explained when their aggregation in solution was taken into consideration. A bis-aminodiphenylsulfide with an IC50 of 0.55 μM was revealed to be the best TR inhibitor described so far.