phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate

Base Information

Chemical Name:phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate
CAS No.:1335556-90-5
Molecular Formula:C₂₇H₂₈FNO₃
Molecular Weight:433.523
Hs Code.:

Synonyms:phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate

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Chemical Property of phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate

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Technology Process of phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate

There total 2 articles about phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 107-10-8,42939-71-9
propylamine

: 1335557-57-7
C₂₅H₂₁FO₅

: 1335556-90-5
phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate

Guidance literature:: propylamine; C₂₅H₂₁FO₅; With acetic acid; In dichloromethane; for 2h;

With sodium tris(acetoxy)borohydride; for 17.5h;

Reference yield:

: C₂₅H₂₃FO₅

: 1335556-90-5
phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane / 1 h

2.1: acetic acid / dichloromethane / 2 h

2.2: 17.5 h

With Dess-Martin periodane; acetic acid; In dichloromethane;

Reference yield: 55.0%

: 852821-06-8
(4aS,8aS,9S)-3-(benzyloxy)-4a-(tert-butyldimethylsilyloxy)-9-(dimethylamino)-8a,9-dihydronaphtho[2,3-d]isoxazole-4,5(4aH,8H)-dione

: 1335556-90-5
phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate

: 1335557-58-8
C₄₇H₅₆FN₃O₇Si

Guidance literature:: phenyl 5-(benzyloxy)-8-fluoro-7-methyl-2-propyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate; With N,N,N,N,-tetramethylethylenediamine; lithium diisopropyl amide; In tetrahydrofuran; hexanes; at -78 ℃; for 0.166667h;

(4aS,8aS,9S)-3-(benzyloxy)-4a-(tert-butyldimethylsilyloxy)-9-(dimethylamino)-8a,9-dihydronaphtho[2,3-d]isoxazole-4,5(4aH,8H)-dione; In tetrahydrofuran; hexanes; at -78 - -20 ℃; for 1h;