[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine

Base Information

Chemical Name:[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine
CAS No.:1240608-97-2
Molecular Formula:C₂₄H₂₁FN₆O
Molecular Weight:428.469
Hs Code.:

Synonyms:[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine

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Chemical Property of [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine

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Technology Process of [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine

There total 8 articles about [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1239719-55-1
4-bromo-2-(4-fluorophenyl)-1-methyl-1H-benzimidazole

: 1079178-13-4
5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-amine

: 1240608-97-2
[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 150 ℃; for 5h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm201710f

Reference yield:

: 75711-00-1
2-chloro-3-methoxy-5-nitropyridine

: 1240608-97-2
[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

2: iron / acetic acid / 1 h / 60 °C

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 5 h / 150 °C / Inert atmosphere; Microwave irradiation

With palladium diacetate; iron; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm201710f

Reference yield:

: 1079178-12-3
3-methoxy-2-(4-methyl-1H-imidazol-1-yl)-5-nitropyridine

: 1240608-97-2
[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[5-methoxy-6-(4-methylimidazol-1-yl)pyridin-3-yl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: iron / acetic acid / 1 h / 60 °C

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 5 h / 150 °C / Inert atmosphere; Microwave irradiation

With palladium diacetate; iron; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In acetic acid; toluene;
DOI:10.1021/jm201710f