5-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-3-[ethyl(oxan-4-yl)amino]-2-methylbenzoic acid

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Chemical Name:5-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-3-[ethyl(oxan-4-yl)amino]-2-methylbenzoic acid
CAS No.:1403596-14-4
Molecular Formula:C₂₃H₃₄N₂O₅
Molecular Weight:418.533
Hs Code.:

Synonyms:5-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-3-[ethyl(oxan-4-yl)amino]-2-methylbenzoic acid

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Chemical Property of 5-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-3-[ethyl(oxan-4-yl)amino]-2-methylbenzoic acid

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Technology Process of 5-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-3-[ethyl(oxan-4-yl)amino]-2-methylbenzoic acid

There total 4 articles about 5-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-3-[ethyl(oxan-4-yl)amino]-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403596-14-4
5-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-3-[ethyl(oxan-4-yl)amino]-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

3.2: 64 h

4.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

4.2: 22 h / 20 °C

5.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / Inert atmosphere

5.2: 16 h / 80 °C / Inert atmosphere

6.1: sodium hydroxide / tetrahydrofuran; methanol / 38 h / 20 - 50 °C

6.2: pH 5

With chloro-trimethyl-silane; iron; sodium carbonate; ammonium chloride; acetic acid; ethylene dibromide; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1403257-79-3
2-methyl-3-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester

: 1403596-14-4
5-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-3-[ethyl(oxan-4-yl)amino]-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / Inert atmosphere

1.2: 16 h / 80 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; methanol / 38 h / 20 - 50 °C

2.2: pH 5

With chloro-trimethyl-silane; ethylene dibromide; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ISOPROPYLAMIDE;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1403596-14-4
5-{1-[(tert-butoxy)carbonyl]azetidin-3-yl}-3-[ethyl(oxan-4-yl)amino]-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

2.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

2.2: 64 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

3.2: 22 h / 20 °C

4.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / Inert atmosphere

4.2: 16 h / 80 °C / Inert atmosphere

5.1: sodium hydroxide / tetrahydrofuran; methanol / 38 h / 20 - 50 °C

5.2: pH 5

With chloro-trimethyl-silane; iron; ammonium chloride; acetic acid; ethylene dibromide; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane;