(E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone

Base Information

Chemical Name:(E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone
CAS No.:63294-82-6
Molecular Formula:C₂₁H₃₀O₄S
Molecular Weight:378.533
Hs Code.:

Synonyms:(E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone

Suppliers and Price of (E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone

Chemical Property:

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Technology Process of (E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone

There total 11 articles about (E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28659-22-5
6-(tetrahydro-2H-pyranyloxy)hexan-1-ol

: 63294-82-6
(E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / pyridine / 0 °C

2: 1.) sodium iodide, 2.) acetic acid / 1.) DMF, 100 deg C, 2.) THF, H₂O, room temperature

3: 94 percent / triethylamine / diethyl ether / 5 h / 40 °C

4: 1.) sodium hydride / 2.) tetrakis(triphenylphosphine)palladium⁽⁰⁾ / 1.) THF, 45 deg C, 10 min; room temperature,30 min, 2.) reflux, 4 h

5: 82.5 percent / hexamethylphosphoric acid triamide / 11 h / 90 °C

With pyridine; sodium hydride; acetic acid; triethylamine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1021/ja00534a030

Reference yield:

: 629-11-8
1,6-hexanediol

: 63294-82-6
(E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone

Guidance literature:: Multi-step reaction with 6 steps

1: 38 percent / p-toluenesulfonic acid / CH₂Cl₂ / 0 °C

2: 93 percent / pyridine / 0 °C

3: 1.) sodium iodide, 2.) acetic acid / 1.) DMF, 100 deg C, 2.) THF, H₂O, room temperature

4: 94 percent / triethylamine / diethyl ether / 5 h / 40 °C

5: 1.) sodium hydride / 2.) tetrakis(triphenylphosphine)palladium⁽⁰⁾ / 1.) THF, 45 deg C, 10 min; room temperature,30 min, 2.) reflux, 4 h

6: 82.5 percent / hexamethylphosphoric acid triamide / 11 h / 90 °C

With pyridine; sodium hydride; toluene-4-sulfonic acid; acetic acid; triethylamine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane;
DOI:10.1021/ja00534a030

Reference yield:

: 5299-60-5
6-hydroxy-hexanoic acid ethyl ester

: 63294-82-6
(E)-9-benzenesulfonyl-15-hydroxy-6-pentadecenoate lactone

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / pyridinium chlorochromate, sodum acetate / CH₂Cl₂ / 1 h / Ambient temperature

2: 71 percent / tetrahydrofuran / 1 h / 0 °C

3: 91 percent / potassium hydroxide / aq. ethanol / 2.5 h / Ambient temperature

4: 60 percent / pyridine / Ambient temperature

5: thionyl chloride / diethyl ether / 4 h / Ambient temperature

6: 94 percent / triethylamine / diethyl ether / 5 h / 40 °C

7: 1.) sodium hydride / 2.) tetrakis(triphenylphosphine)palladium⁽⁰⁾ / 1.) THF, 45 deg C, 10 min; room temperature,30 min, 2.) reflux, 4 h

8: 82.5 percent / hexamethylphosphoric acid triamide / 11 h / 90 °C

With pyridine; potassium hydroxide; thionyl chloride; sodium acetate; sodium hydride; triethylamine; pyridinium chlorochromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/ja00534a030