28659-22-5Relevant articles and documents
tert-butyl ethers: Renaissance of an alcohol protecting group. Facile cleavage with cerium(III) chloride/sodium iodide
Bartoli, Giuseppe,Bosco, Marcella,Carlone, Armando,Locatelli, Manuela,Marcantoni, Enrico,Melchiorre, Paolo,Sambri, Letizia
, p. 905 - 910 (2007/10/03)
The tert-butoxy derivative is one of the most underused alcohol protecting groups. After having developed an easy and useful protocol for its introduction, we offer here a simple procedure for its removal by treatment with anhydrous CeCl3 and NaI in CH3CN. The procedure led to the successful cleavage of aliphatic and aromatic tert-butyl ethers and was compatible with various other functionalities and protecting groups present in the molecule.