u202fN-(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)methanesulfonamide

Base Information

• Chemical Name: u202fN-(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)methanesulfonamide
• CAS No.: 1022958-40-2
• Molecular Formula: C₁₁H₁₀Cl₂N₄O₂S
• Molecular Weight: 333.198
• Mol file: 1022958-40-2.mol

Synonyms:u202fN-(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)methanesulfonamide

Chemical Property of u202fN-(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of u202fN-(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)methanesulfonamide

There total 3 articles about u202fN-(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.3%

N1-(2,5-dichloropyrimidin-4-yl)benzene-1,2-diamine (953048-66-3) + methanesulfonyl chloride (124-63-0) → u202fN-(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)methanesulfonamide (1022958-40-2)

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 ℃; for 2.5h; Cooling with ice;

Reference yield:

1,2-diamino-benzene (95-54-5) → u202fN-(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)methanesulfonamide (1022958-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 80 °C

2: pyridine / dichloromethane / 2.5 h / 20 °C / Cooling with ice

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; isopropyl alcohol;

DOI:10.1016/j.ejmech.2018.09.012

Reference yield:

→ u202fN-(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)methanesulfonamide (1022958-40-2)

Guidance literature:

upstream raw materials:

N¹-(2,5-dichloropyrimidin-4-yl)benzene-1,2-diamine

methanesulfonyl chloride

1,2-diamino-benzene

Downstream raw materials:

N-(2-(2-(3-(2-aminoethoxy)phenylamino)-5-chloropyrimidin-4-ylamino)phenyl)methanesulfonamide

N-(2-((5-chloro-2-((2-methoxy-6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide