(5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Base Information

Chemical Name:(5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one
CAS No.:178230-62-1
Molecular Formula:C₃₇H₄₄O₈Si
Molecular Weight:644.837
Hs Code.:

(5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Synonyms:(5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

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Chemical Property of (5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

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Technology Process of (5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

There total 3 articles about (5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 21087-29-6
trans-3-phenylprop-2-enyl chloride

: 112711-16-7
(5R,5aR,8aR,9R)-9-((tert-butyldimethylsilyl)oxy)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one

: 178230-62-1
(5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

: 178101-48-9
(5R,5aR,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; 1.) -78 deg C, 15 min, 2.) -78 deg C to 20 deg C, overnight;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 178230-62-1
(5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / imidazole / dimethylformamide / 15 h / 20 °C

2: 44 percent / LDA / tetrahydrofuran; hexane / 1.) -78 deg C, 15 min, 2.) -78 deg C to 20 deg C, overnight

With 1H-imidazole; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

: 518-28-5
podofilox

: 178230-62-1
(5R,5aS,8aR,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-5a-((E)-3-phenyl-allyl)-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / imidazole / dimethylformamide / 15 h / 20 °C

2: 44 percent / LDA / tetrahydrofuran; hexane / 1.) -78 deg C, 15 min, 2.) -78 deg C to 20 deg C, overnight

With 1H-imidazole; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;