2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester

Base Information

Chemical Name:2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester
CAS No.:76292-78-9
Molecular Formula:C₁₅H₁₆F₃NO₄
Molecular Weight:331.292
Hs Code.:

Synonyms:2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester

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Chemical Property of 2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester

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Technology Process of 2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester

There total 2 articles about 2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 6829-40-9
aminomalonic acid diethyl ester

: 76292-78-9
2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester

Guidance literature:: With gallium(III) bromide; In dichloromethane; at 30 ℃; for 0.5h; Molecular sieve; Inert atmosphere;
DOI:10.1039/c5cc03341a

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 13433-00-6
diethyl aminomalonate hydrochloride

: 76292-78-9
2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester

Guidance literature:: DOI:10.1016/S0040-4039(00)78997-0

Reference yield: 88.0%

: 1-(1-methyl-1H-indol-4-yl)prop-2-en-1-ol

: 76292-78-9
2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester

: diethyl (6S,9R)-2-methyl-9-(4-(trifluoromethyl)phenyl)-6-vinyl-2,6,8,9-tetrahydro-7H-azepino[3,4,5-cd]indole-7,7-dicarboxylate

Guidance literature:: 1-(1-methyl-1H-indol-4-yl)prop-2-en-1-ol; With (S)-(+)-N-(3,5-dioxa-4-phosphacyclohepta-[2,1-a;3,4-a′]dinaphthalen-4-yl)dibenz[b,f]azepine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; In dichloromethane; at 20 ℃; Schlenk technique; Inert atmosphere; Molecular sieve;

2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester; With zinc trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1.5h; stereoselective reaction; Schlenk technique; Inert atmosphere; Molecular sieve;
DOI:10.1021/acs.orglett.0c04132