4-acetyl-2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine

Base Information

• Chemical Name: 4-acetyl-2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine
• CAS No.: 1004764-61-7
• Molecular Formula: C₂₂H₂₂N₂O₂S
• Molecular Weight: 378.495
• Mol file: 1004764-61-7.mol

Synonyms:4-acetyl-2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine

Chemical Property of 4-acetyl-2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-acetyl-2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine

There total 5 articles about 4-acetyl-2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine hydrochloride (1004764-60-6) + acetyl chloride (75-36-5) → 4-acetyl-2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine (1004764-61-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 64.0%

C20H20N2OS (1004853-34-2) + acetyl chloride (75-36-5) → 4-acetyl-2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine (1004764-61-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/cmdc.201100248

Reference yield:

4-(benzyloxy)-N-(2-oxoazepan-3-yl)benzamide (1004764-59-3) → 4-acetyl-2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine (1004764-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Lawessons reagent; pyridine / 20 h / 100 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

With Lawessons reagent; pyridine; triethylamine; In dichloromethane;

DOI:10.1002/cmdc.201100248

upstream raw materials:

2-[4-(benzyloxy)phenyl]-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepine hydrochloride

acetyl chloride

4-(benzyloxy)-N-(2-oxoazepan-3-yl)benzamide

C₂₀H₂₀N₂OS

Downstream raw materials:

4-(4-acetyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-b]azepin-2-yl)phenol

C₂₃H₃₁N₃O₂S