erythro-Methyl <2-<(methoxycarbonyl)oxy>-1,2-diphenylethyl>carbamate

Base Information

• Chemical Name: erythro-Methyl <2-<(methoxycarbonyl)oxy>-1,2-diphenylethyl>carbamate
• CAS No.: 86217-45-0
• Molecular Formula: C₁₆H₁₇NO₃
• Molecular Weight: 271.316
• Mol file: 86217-45-0.mol

Synonyms:erythro-Methyl <2-<(methoxycarbonyl)oxy>-1,2-diphenylethyl>carbamate

Chemical Property of erythro-Methyl <2-<(methoxycarbonyl)oxy>-1,2-diphenylethyl>carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-Methyl <2-<(methoxycarbonyl)oxy>-1,2-diphenylethyl>carbamate

There total 2 articles about erythro-Methyl <2-<(methoxycarbonyl)oxy>-1,2-diphenylethyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dl-erythro-1,2-diphenyl-2-hydroxyethylamine (23412-95-5) + methyl chloroformate (79-22-1) → erythro-Methyl <2-<(methoxycarbonyl)oxy>-1,2-diphenylethyl>carbamate (86217-45-0)

Guidance literature:

With pyridine; In tetrahydrofuran; at -15 ℃; for 3h;

DOI:10.1021/jo00163a019

Reference yield:

benzoin oxime (441-38-3) → erythro-Methyl <2-<(methoxycarbonyl)oxy>-1,2-diphenylethyl>carbamate (86217-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / HCl, H₂ / 5percent Pd/C / ethanol / 2.5 h / 3102.9 Torr

2: 95 percent / pyridine / tetrahydrofuran / 3 h / -15 °C

With pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00163a019

Reference yield: 95.0%

erythro-Methyl <2-<(methoxycarbonyl)oxy>-1,2-diphenylethyl>carbamate (86217-45-0) → cis-4,5-diphenyl-1,3-oxazolidin-2-one (86286-49-9)

Guidance literature:

With sodium methylate; In tetrahydrofuran; for 12h; Ambient temperature;

DOI:10.1021/jo00163a019

upstream raw materials:

dl-erythro-1,2-diphenyl-2-hydroxyethylamine

methyl chloroformate

benzoin oxime

Downstream raw materials:

cis-4,5-diphenyl-1,3-oxazolidin-2-one

(4S,5R)-4,5-diphenyl-1,3-oxazolidin-2-one

(4R,5S)-4,5-diphenyl-1,3-oxazolidin-2-one

(4R,5S)-cis-4,5-Diphenyl-2-oxazolidone-3-carbamyl Chloride