Toluene-4-sulfonic acid 1-hydroxymethyl-2-methylene-cyclohexylmethyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid 1-hydroxymethyl-2-methylene-cyclohexylmethyl ester
• CAS No.: 104654-73-1
• Molecular Formula: C₁₆H₂₂O₄S
• Molecular Weight: 310.414
• Mol file: 104654-73-1.mol

Synonyms:Toluene-4-sulfonic acid 1-hydroxymethyl-2-methylene-cyclohexylmethyl ester

Chemical Property of Toluene-4-sulfonic acid 1-hydroxymethyl-2-methylene-cyclohexylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Toluene-4-sulfonic acid 1-hydroxymethyl-2-methylene-cyclohexylmethyl ester

There total 3 articles about Toluene-4-sulfonic acid 1-hydroxymethyl-2-methylene-cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Methylene-1-(toluene-4-sulfonyloxymethyl)-cyclohexanecarboxylic acid ethyl ester (104654-71-9) → Toluene-4-sulfonic acid 1-hydroxymethyl-2-methylene-cyclohexylmethyl ester (104654-73-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1246/cl.1985.1785

Reference yield:

Ethyl 2-methyl-1-cyclohex-1-ene carboxylate (104654-69-5) → Toluene-4-sulfonic acid 1-hydroxymethyl-2-methylene-cyclohexylmethyl ester (104654-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / LDA / tetrahydrofuran / -78 °C

2: 80 percent / pyridine

3: 99 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; pyridine;

DOI:10.1246/cl.1985.1785

Reference yield:

1-Hydroxymethyl-2-methylene-cyclohexanecarboxylic acid ethyl ester (104654-70-8) → Toluene-4-sulfonic acid 1-hydroxymethyl-2-methylene-cyclohexylmethyl ester (104654-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine

2: 99 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran; pyridine;

DOI:10.1246/cl.1985.1785

upstream raw materials:

2-Methylene-1-(toluene-4-sulfonyloxymethyl)-cyclohexanecarboxylic acid ethyl ester

Ethyl 2-methyl-1-cyclohex-1-ene carboxylate

1-Hydroxymethyl-2-methylene-cyclohexanecarboxylic acid ethyl ester

Downstream raw materials:

2-(Hydroxymethyl)-1,2-dimethylcyclohexanol

1,6-Dioxa-dispiro[2.0.3.4]undecane