benzyl (3-(7-bromo-1-carbamoyl-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenyl)carbamate

Base Information

Chemical Name:benzyl (3-(7-bromo-1-carbamoyl-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenyl)carbamate
CAS No.:1352837-14-9
Molecular Formula:C₂₈H₂₃BrN₄O₃
Molecular Weight:543.42
Hs Code.:

Synonyms:benzyl (3-(7-bromo-1-carbamoyl-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenyl)carbamate

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Chemical Property of benzyl (3-(7-bromo-1-carbamoyl-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenyl)carbamate

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Technology Process of benzyl (3-(7-bromo-1-carbamoyl-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenyl)carbamate

There total 10 articles about benzyl (3-(7-bromo-1-carbamoyl-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352837-12-7
4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylic acid

: 1352837-14-9
benzyl (3-(7-bromo-1-carbamoyl-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenyl)carbamate

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 69022-35-1
2-methyl-3-amino-benzonitrile

: 1352837-14-9
benzyl (3-(7-bromo-1-carbamoyl-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenyl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

3.1: ammonium acetate; acetic acid / 95 °C

4.1: 140 °C

5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / Inert atmosphere

6.1: hydrogenchloride / toluene; 1,4-dioxane / 20 °C / Inert atmosphere

7.1: palladium 10% on activated carbon / xylene / 120 °C

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 4 h / 20 °C

8.3: pH 5

9.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; ammonium acetate; water; diisobutylaluminium hydride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; xylene;

Reference yield:

: 71516-35-3
2-methyl-3-nitrobenzonitrile

: 1352837-14-9
benzyl (3-(7-bromo-1-carbamoyl-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenyl)carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

2.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

3.2: 0.5 h / 20 °C / Cooling with ice

4.1: ammonium acetate; acetic acid / 95 °C

5.1: 140 °C

6.1: zinc; ammonium chloride / tetrahydrofuran; methanol / Inert atmosphere

7.1: hydrogenchloride / toluene; 1,4-dioxane / 20 °C / Inert atmosphere

8.1: palladium 10% on activated carbon / xylene / 120 °C

9.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 4 h / 20 °C

9.3: pH 5

10.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; ammonium acetate; water; diisobutylaluminium hydride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; xylene;