Technology Process of (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-(methyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)butyl)phenoxy)methyl)cyclopropyl)methanone trifluoroacetate
There total 16 articles about (4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(1-((2,5-dichloro-4-(4-(methyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)butyl)phenoxy)methyl)cyclopropyl)methanone trifluoroacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(2,5-dichloro-4-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)methoxy)phenyl)butyl methanesulfonate; 1-deoxy-1-(methylamino)-D-glucitol;
With
triethylamine; potassium iodide;
In
N,N-dimethyl-formamide;
at 75 ℃;
trifluoroacetic acid;
- Guidance literature:
-
Multi-step reaction with 12 steps
1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere
2: borane-THF / tetrahydrofuran / 4 h / 50 °C
3: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
4: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C
5: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
6: sodium tetrahydroborate / 1,2-dimethoxyethane; water / 2 h / 0 °C
7: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
8: potassium carbonate / acetone / 55 °C
9: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
10: rhodium contaminated with carbon; hydrogen / ethyl acetate
11: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
12: triethylamine; potassium iodide / N,N-dimethyl-formamide / 75 °C
With
bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; borane-THF; rhodium contaminated with carbon; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium iodide; sodium hydroxide;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: borane-THF / tetrahydrofuran / 4 h / 50 °C
2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
3: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C
4: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
5: sodium tetrahydroborate / 1,2-dimethoxyethane; water / 2 h / 0 °C
6: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
7: potassium carbonate / acetone / 55 °C
8: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
9: rhodium contaminated with carbon; hydrogen / ethyl acetate
10: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
11: triethylamine; potassium iodide / N,N-dimethyl-formamide / 75 °C
With
bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; borane-THF; rhodium contaminated with carbon; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
