N-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-yl}cyclopropanecarboxamide

Base Information

Chemical Name:N-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-yl}cyclopropanecarboxamide
CAS No.:1448015-71-1
Molecular Formula:C₁₉H₂₃BN₂O₃S
Molecular Weight:370.28
Hs Code.:

Synonyms:N-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-yl}cyclopropanecarboxamide

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Chemical Property of N-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-yl}cyclopropanecarboxamide

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Technology Process of N-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-yl}cyclopropanecarboxamide

There total 3 articles about N-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-yl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 313405-50-4
cyclopropanecarboxylic acid [4-(4-bromophenyl)thiazol-2-yl]amide

: 73183-34-3
bis(pinacol)diborane

: 1448015-71-1
N-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-yl}cyclopropanecarboxamide

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1002/cmdc.201300007

Reference yield:

: 2103-94-8
4-(4-bromophenyl)-1,3-thiazol-2-amine

: 1448015-71-1
N-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1002/cmdc.201300007

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1448015-71-1
N-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]thiazol-2-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 18 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; 1: |Hantzsch Thiazole Synthesis;
DOI:10.1002/cmdc.201300007