(E,E)-1-(4-hydroxystyryl)-4-(3-hydroxystyryl)benzene

Base Information

• Chemical Name: (E,E)-1-(4-hydroxystyryl)-4-(3-hydroxystyryl)benzene
• CAS No.: 1256334-07-2
• Molecular Formula: C₂₂H₁₈O₂
• Molecular Weight: 314.384
• Mol file: 1256334-07-2.mol

Synonyms:(E,E)-1-(4-hydroxystyryl)-4-(3-hydroxystyryl)benzene

Chemical Property of (E,E)-1-(4-hydroxystyryl)-4-(3-hydroxystyryl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E,E)-1-(4-hydroxystyryl)-4-(3-hydroxystyryl)benzene

There total 8 articles about (E,E)-1-(4-hydroxystyryl)-4-(3-hydroxystyryl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(E,E)-1-[4-(methoxymethoxy)styryl]-4-[3-(methoxymethoxy)styryl]benzene (1256334-11-8) → (E,E)-1-(4-hydroxystyryl)-4-(3-hydroxystyryl)benzene (1256334-07-2)

Guidance literature:

With hydrogenchloride; In methanol; chloroform; water; at 20 ℃; for 24h;

DOI:10.1021/jm1006929

Reference yield:

4-(methoxymethoxy)-1-ethynylbenzene (220882-37-1) → (E,E)-1-(4-hydroxystyryl)-4-(3-hydroxystyryl)benzene (1256334-07-2)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen / ethanol; ethyl acetate / 1 h / 760.05 Torr

2: phenyl carbamate; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 22 h / 110 °C / Inert atmosphere

3: sodium methylate / methanol; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

4: hydrogenchloride / methanol; chloroform; water / 24 h / 20 °C

With hydrogenchloride; phenyl carbamate; hydrogen; sodium methylate; palladium diacetate; potassium carbonate; In methanol; ethanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; 2: Heck reaction / 3: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/jm1006929

Reference yield:

1-(methoxymethoxy)-4-vinylbenzene (142357-48-0) → (E,E)-1-(4-hydroxystyryl)-4-(3-hydroxystyryl)benzene (1256334-07-2)

Guidance literature:

Multi-step reaction with 3 steps

1: phenyl carbamate; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 22 h / 110 °C / Inert atmosphere

2: sodium methylate / methanol; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere

3: hydrogenchloride / methanol; chloroform; water / 24 h / 20 °C

With hydrogenchloride; phenyl carbamate; sodium methylate; palladium diacetate; potassium carbonate; In methanol; chloroform; water; N,N-dimethyl-formamide; 1: Heck reaction / 2: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/jm1006929

upstream raw materials:

4-(methoxymethoxy)-1-ethynylbenzene

1-(methoxymethoxy)-4-vinylbenzene

3-methoxymethoxybenzaldehyde

(E,E)-1-[4-(methoxymethoxy)styryl]-4-[3-(methoxymethoxy)styryl]benzene