(5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol

Base Information

Chemical Name:(5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol
CAS No.:1301725-75-6
Molecular Formula:C₁₇H₂₇NO₄S
Molecular Weight:341.472
Hs Code.:

Synonyms:(5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol

Suppliers and Price of (5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol

Chemical Property:

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Technology Process of (5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol

There total 4 articles about (5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1301725-73-4
(2R)-N-(tert-butylsulfonyl)-1-(4-methoxyphenyl)-3-(2-methyloxiran-2-yl)propan-2-ylamine

: 1301725-75-6
(5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 24h; optical yield given as %de; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201100091

Reference yield:

: 5703-26-4
4-Methoxyphenylacetaldehyde

: 1301725-75-6
(5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate; indium / tetrahydrofuran / 1 h / 23 °C / Inert atmosphere

1.2: 5 h / 60 °C / Inert atmosphere

2.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 0 °C

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere

With titanium(IV) tetraethanolate; indium; sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100091

Reference yield:

: 702-23-8
2-(4-Methoxyphenyl)ethanol

: 1301725-75-6
(5R)-N-(tert-butylsulfonyl)-5-(4-methoxybenzyl)-3-methylpyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

2.1: titanium(IV) tetraethanolate; indium / tetrahydrofuran / 1 h / 23 °C / Inert atmosphere

2.2: 5 h / 60 °C / Inert atmosphere

3.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 0 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere

With titanium(IV) tetraethanolate; indium; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100091