(S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol

Base Information

Chemical Name:(S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol
CAS No.:1027834-41-8
Molecular Formula:C₂₃H₂₉NO₄
Molecular Weight:383.488
Hs Code.:

Synonyms:(S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol

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Chemical Property of (S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol

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Technology Process of (S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol

There total 5 articles about (S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78385-26-9
3-bromomethyl-3-methyloxetane

: 1027834-41-8
(S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: CsCO₃ / H₂O / 2 h

1.2: 81 percent / dimethylformamide / 24 h / 20 °C

2.1: 90 percent / BF₃*OEt₂ / CH₂Cl₂ / 8 h / -30 - 20 °C

3.1: 78 percent / LAH / tetrahydrofuran / 0.5 h / 0 °C

4.1: H₂ / Pd(OH)2/C / methanol / 20 °C

5.1: 952 mg / K₂CO₃ / acetonitrile / 20 °C

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1002/ejoc.200300199

Reference yield:

: 1026639-43-9
[(S)-1-Hydroxymethyl-2-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-carbamic acid benzyl ester

: 1027834-41-8
(S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd(OH)2/C / methanol / 20 °C

2: 952 mg / K₂CO₃ / acetonitrile / 20 °C

With hydrogen; potassium carbonate; palladium dihydroxide; In methanol; acetonitrile;
DOI:10.1002/ejoc.200300199

Reference yield:

: 613264-81-6
(S)-2-Benzyloxycarbonylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propionic acid benzyl ester

: 1027834-41-8
(S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / LAH / tetrahydrofuran / 0.5 h / 0 °C

2: H₂ / Pd(OH)2/C / methanol / 20 °C

3: 952 mg / K₂CO₃ / acetonitrile / 20 °C

With lithium aluminium tetrahydride; hydrogen; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1002/ejoc.200300199