(+)-(2R)-2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid methyl ester

Base Information

Chemical Name:(+)-(2R)-2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid methyl ester
CAS No.:573703-15-8
Molecular Formula:C₂₇H₃₀NO₃P
Molecular Weight:447.514
Hs Code.:

Synonyms:(+)-(2R)-2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid methyl ester

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Chemical Property of (+)-(2R)-2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid methyl ester

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Technology Process of (+)-(2R)-2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid methyl ester

There total 5 articles about (+)-(2R)-2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25726-04-9
phenylglyoxylyl chloride

: 573703-15-8
(+)-(2R)-2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 91 percent / DMAP; pyridine / CH₂Cl₂ / 0 °C

2.1: 69 percent / TiCl₄; Et₃N / CH₂Cl₂ / 36 h / 20 °C

3.1: Cp₂Zr(H)Cl / CH₂Cl₂ / 0.17 h / 20 °C

3.2: Me₂Zn / toluene / -78 - -40 °C

3.3: TiCl(O-i-Pr)3 / toluene; CH₂Cl₂ / 24 h / -40 °C

4.1: t-BuOK; H₂O / tetrahydrofuran / 5 h / 70 °C

5.1: 58 mg / methanol; hexane / 0.25 h

With pyridine; dmap; Schwartz's reagent; potassium tert-butylate; water; titanium tetrachloride; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol0347141

Reference yield:

: 88002-15-7
Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester

: 573703-15-8
(+)-(2R)-2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 69 percent / TiCl₄; Et₃N / CH₂Cl₂ / 36 h / 20 °C

2.1: Cp₂Zr(H)Cl / CH₂Cl₂ / 0.17 h / 20 °C

2.2: Me₂Zn / toluene / -78 - -40 °C

2.3: TiCl(O-i-Pr)3 / toluene; CH₂Cl₂ / 24 h / -40 °C

3.1: t-BuOK; H₂O / tetrahydrofuran / 5 h / 70 °C

4.1: 58 mg / methanol; hexane / 0.25 h

With Schwartz's reagent; potassium tert-butylate; water; titanium tetrachloride; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol0347141

Reference yield:

: 611-73-4
Benzoylformic acid

: 573703-15-8
(+)-(2R)-2-diphenylphosphinoylamino-2-phenyloct-3-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70 percent / α,α-dichloromethyl methyl ether / 50 °C

2.1: 91 percent / DMAP; pyridine / CH₂Cl₂ / 0 °C

3.1: 69 percent / TiCl₄; Et₃N / CH₂Cl₂ / 36 h / 20 °C

4.1: Cp₂Zr(H)Cl / CH₂Cl₂ / 0.17 h / 20 °C

4.2: Me₂Zn / toluene / -78 - -40 °C

4.3: TiCl(O-i-Pr)3 / toluene; CH₂Cl₂ / 24 h / -40 °C

5.1: t-BuOK; H₂O / tetrahydrofuran / 5 h / 70 °C

6.1: 58 mg / methanol; hexane / 0.25 h

With pyridine; dmap; Schwartz's reagent; Dichloromethyl methyl ether; potassium tert-butylate; water; titanium tetrachloride; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol0347141