88002-15-7

Basic information

• Product Name: Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester
• Synonyms: Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester
• CAS NO: 88002-15-7
• Molecular Weight: 364.485
• Mol File: 88002-15-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester(88002-15-7)
• EPA Substance Registry System: Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester(88002-15-7)

Safety Data

• Hazardous Substances Data: 88002-15-7(Hazardous Substances Data)

Upstream product

• 71804-27-8 (1R,2S,5R)-(+)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl chloroacetate 
• 65253-04-5 (-)-8-phenylmenthol 
• 611-73-4 Benzoylformic acid 
• 25726-04-9 phenylglyoxylyl chloride 

Downstream Products

• 88002-20-4 (S)-3,3,4,4-Tetramethyl-2-phenyl-oxetane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 153993-89-6 (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate 
• 88002-09-9 (R)-2-Hydroxy-2-phenyl-succinic acid 4-ethyl ester 1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester 
• 88002-27-1 (S)-2-Hydroxy-2-phenyl-succinic acid 4-ethyl ester 1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester 
• 88080-34-6 (S)-3,3-Diethoxy-2-phenyl-oxetane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 88002-02-2 (R)-3,3-Diethoxy-2-phenyl-oxetane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 88002-09-9 4-Ethyl-1-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>-2-hydroxy-2-phenylsuccinat 
• 88002-02-2 <(1R,2S,5R)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>-3,3-diethoxy-2-phenyl-2-oxetancarboxylat 
• 113648-94-5 2-Acetyl-3,3-dimethyl-endo-7-phenyl-4,6-dioxa-2-azabicyclo<3.2.0>heptan-7-carbonsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>ester 
• 113648-95-6 4-Acetyl-3,3-dimethyl-endo-7-phenyl-2,6-dioxa-4-azabicyclo<3.2.0>heptan-7-carbonsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>ester 
• 168104-52-7 (S)-Hydroxy-(4-hydroxymethyl-phenyl)-phenyl-acetic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 168104-63-0 (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (S)-α-hydroxy-α-<4-(3-fluoropropyl)phenyl>benzeneacetate 
• 573703-10-3 (2R,3E)-2-hydroxy-2-phenyloct-3-enoic acid (-)-8-phenylmenthyl ester 
• 113648-96-7 2-(3-Acetyl-5-methoxy-2,2-dimethyl-4-oxazolidinyl)-2-hydroxy-2-phenylessigsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>ester 

Relevant articles and documents

Selective Formation of Functionalized α-Quaternary Malononitriles toward 5,5-Disubstituted Pyrrolopyrimidinones

A modular, selective approach to complex α-tertiary substituted malononitriles is reported. The method takes advantage of β-ester-substituted α,α-dinitrile alkenes as highly reactive, chemoselective electrophiles for 1,4-additions with organometallic nucleophiles to produce functionally and sterically dense all-carbon quaternary centers. In the presence of a chiral ester auxiliary bearing an aromatic ring, the 1,4-addition occurs with good to excellent selectivity due to favorable cation-π interactions. The highly functionalized malononitriles represent versatile building blocks and can be applied toward efficient, highly selective syntheses of 5,5-disubstituted pyrrolopyrimidinones.

Diatereoselectivity in the O-H Insertion Reactions of Rhodium Carbenoids Derived from Phenyldiazoacetates of Chiral Alcohols. Preparation of α-Hydroxy and α-Alkoxy Esters

A series of phenyldiazoacetates 3 derived from enantiomerically pure alcohols ((-)-borneol, (+)-menthol, (-)-menthol, (-)-8-phenylmenthol, (-)-trans-2-phenylcyclohexanol, (+)-trans-2-phenyl-cyclohexanol, and (-)-10-(dicyclohexylsulfamoyl)-D-isoborneol) were prepared from the corresponding α-keto esters 1 by way of the tosylhydrazones 2.Rhodium(II)-catalyzed decomposition of the diazoacetates 3 in the presence of water or alcohols resulted in carbenoid O-H insertion reactions to give the corresponding 2-hydroxy- or 2-alkoxyphenylacetates in good yield, but with varying degrees of diastereoselectivity.A range of rhodium(II) and other metal catalysts were investigated, with rhodium(II) acetate and rhodium(II) acetamide giving the best results.The stereochemistry of the major diastereomer was proved in most cases by independent synthesis from a mandelic acid derivative of known configuration.Possible mechanisms are discussed.

Asymmetric syntheses with a new optically active perhydronaphthalene based chiral auxiliary

(1R,4aS,8S,8aS)-8-(5'-Methoxy-2'-methylphenyl)-8-methyldecahydro-1-nap hthalenol 3a is a highly efficient chiral auxiliary in the Diels-Alder addition of its acrylate ester 5 and in the DIBAL-H and Grignard reactions of its phenylglyoxylate ester 7.